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RESEARCH PRODUCT
The Role of the Major Histocompatibility Gene Complex in Murine Cytotoxic T Cell Responses
Klaus PfizenmaierHerrnann WagnerM. Röllinghoffsubject
T cellchemical and pharmacologic phenomenaBiologyMHC restrictionMajor histocompatibility complexmedicine.anatomical_structureAntigenImmunologyMHC class Imedicinebiology.proteinCytotoxic T cellAntigen-presenting cellCD8description
Publisher Summary An interpretation of the function of major histocompatibility complex (MHC) in cytotoxic T cell responses requires making certain assumptions, which, because of the lack of experimental data, are often based on intuition. This chapter discusses some specific aspects of the role of MHC in cytotoxic T cell responses. It also summarizes the expression of T cell-mediated responses to alloantigens. It also focuses on H-2-restricted cytotoxic T lymphocytes (CTL) responses and discusses the influence of the MHC on cytotoxic T cell specificity and CTL responsiveness against foreign antigens. T cell responses to alloantigens mirror all the functional activities seen in H-2-restricted T cell responses to foreign antigens. Because of the high frequency of T cells for a given alloantigen, it is postulated that the T cell receptor repertoire is driven by H-2 antigens, as originally suggested for B cells. The high frequency of T cells for alloantigens reflects the degree of relatedness of alloantigens with the host's own H-2 antigens. Experimental tumors are grouped according to their mode of induction. The chapter discusses some of the key features of cell-mediated cytotoxic immune responses to syngeneic tumors and reviews the most frequently used murine tumors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-01-01 |