6533b870fe1ef96bd12cefee

RESEARCH PRODUCT

Second-Line Endocrine Treatment

G. H. Jacobi

subject

Oncologymedicine.medical_specialtybusiness.industryCyproterone acetatemedicine.diseasechemistry.chemical_compoundProstate cancerAndrogen synthesisCastrationSecond linechemistryInternal medicinemedicineEndocrine systemMedroxyprogesterone acetatebusinessHormonemedicine.drug

description

It was a milestone of cancer therapy in general when Huggins et al. [1] in 1941 first reported the beneficial clinical effects of bilateral orchiectomy in patients with prostate cancer, and the use of castration or estrogens as standard therapy remained the first- line treatment for many years. It was furthermore the beginning of a development which, over the following decades, led to the manipulation of testicular androgen synthesis and to attempts to eliminate other possible sources of male hormones.

yearjournalcountryeditionlanguage
1988-01-01
https://doi.org/10.1007/978-3-642-73238-6_10