Delayed neonatal visual evoked potentials are associated to asymmetric growth pattern in twins

6533b870fe1ef96bd12cf0ea

RESEARCH PRODUCT

Delayed neonatal visual evoked potentials are associated to asymmetric growth pattern in twins

Ettore Piro Giuseppe Puccio Agnese Suppiej Raffaele Falsaperla Giovanni Corsello

subject

Male medicine.medical_specialty genetic structures Twins Socio-culturale Visual system 050105 experimental psychology Fetal Development Correlation 03 medical and health sciences Child Development 0302 clinical medicine Physiology (medical)Internal medicine medicine Humans Visual Pathways 0501 psychology and cognitive sciences Latency (engineering)Visual evoked potential latency Ponderal Index Body mass index Visual Cortex business.industry 05 social sciences Infant Newborn Postmenstrual Age Twin Gestational age Electroencephalography Intrauterine growth Anthropometry Asymmetric growth Body mass index; Intrauterine growth; Ponderal Index; Twins; Visual evoked potential latency Sensory Systems Neurology Cardiology Evoked Potentials Visual Female Neurology (clinical)business Body mass index 030217 neurology & neurosurgery

description

Abstract Objectives To study the association between intrauterine growth and visual pathways maturation by neonatal visual evoked potentials (VEPs) in twins, in view of a possible prognostic role. Methods Seventy-four twin neonates from 37 pregnancies were selected based on gestational age of more than 30 weeks and uneventful perinatal clinical course. Flash VEPs were recorded at the same postmenstrual age in each twin pair. The association between P2 latency and anthropometric variables at birth was analyzed by comparison within each twin pair and regarding each variable as ordered difference between the two twins. Results Analysis of differences within each twin pair highlighted that inter-twin difference in P2 latency was significantly related to difference in ponderal index (PI) (p = 0.048). Expressing the difference in latency as a categorical binary variable, the correlation was significant for both difference in PI, (median difference = −0.36, 95% CI −0.54 to −0.14, p = 0.001) and difference in body mass index (BMI), (median difference = −1.06, 95% CI −1.74 to −0.29, p = 0.006). Conclusions Lower values of PI and BMI differences are associated to delayed VEP latency in twin pairs. Significance VEP latency suggests reduced myelination of visual pathways when difference in growth pattern occurs in twins.

year	journal	country	edition	language
2020-01-01	Clinical Neurophysiology

https://doi.org/10.1016/j.clinph.2019.12.407