6533b870fe1ef96bd12cfb52
RESEARCH PRODUCT
Oxyphytosterols are present in plasma of healthy human subjects
André GrandgirardLucy MartineEtienne SémonLuc DemaisonOlivier BerdeauxCorinne JoffreCatherine Cordeletsubject
AdultMaleMedicine (miscellaneous)Mass spectrometryGas Chromatography-Mass Spectrometry03 medical and health sciences0404 agricultural biotechnologyBlood plasmaHumansComputingMilieux_MISCELLANEOUS030304 developmental biology0303 health sciencesNutrition and DieteticsChromatographyPlasma samplesChemistryHealthy subjectsPhytosterols04 agricultural and veterinary sciencesMiddle AgedSitosterols040401 food science3. Good health[SDV.AEN] Life Sciences [q-bio]/Food and NutritionHuman plasmaFemaleOxidation-Reduction[SDV.AEN]Life Sciences [q-bio]/Food and Nutritiondescription
The oxidised derivatives of phytosterols (oxyphytosterols) were identified in plasma samples from thirteen healthy human volunteers, using MS. All the samples contained noticeable quantities of (24R)-5b,6b-epoxy-24-ethylcholestan-3b-ol (b-epoxysitostanol) and (24R)-ethylcholestan-3b,5a,6b-triol (sitostanetriol) and also trace levels of (24R)-5a,6a-epoxy-24-ethylcholestan-3b-ol (a-epoxysitostanol), (24R)-methylcholestan-3b,5a,6b-triol (campestanetriol) and (24R)-ethylch olest-5-en-3b-ol-7-one(7-ketositosterol). The amounts of these oxyphytosterols in plasma varied from 4·8 to 57·2 ng/ml. There are two possibilities concerning the origin of these compounds. First, they could come from the small amounts of oxyphytosterols in food. Second, they could originate from the in vivo oxidation of phytosterols in plasma. Very few data actually exist concerning these compounds. Their identification in human samples suggests that further research is necessary in this field. Oxyphytosterols: Phytosterols: Human plasma: Mass spectrometry
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-30 | British Journal of Nutrition |