6533b870fe1ef96bd12d0399
RESEARCH PRODUCT
Zur Frage des Vorkommens von Isopropylnoradrenalin in Herz und Nebenniere
Erich Muschollsubject
PharmacologyAuriclemedicine.medical_specialtyChemistryPharmacology toxicologyUterusGeneral Medicinemedicine.anatomical_structureBlood pressureEndocrinologyInternal medicineIsoprenalinemedicineAdrenal medullamedicine.drugdescription
1. Extracts of adrenal glands and heart tissue of the cat were prepared and chromatographed on paper. The regions corresponding to the RF values of noradrenaline, adrenaline and isoprenaline (isopropylnoradrenaline) were eluted. The eluates were assayed on the blood pressure, the isolated auricle and the isolated uterus of the rat. Differential assay on these preparations proved to be specific and extremely sensitive for isoprenaline. 2. There was no evidence for the occurrence of isoprenaline in the adrenal medulla or the heart of the cat. The method used is sufficiently sensitive to detect 0,2% of isoprenaline in the total catechol amines of the heart and 0,007% in the adrenals.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1959-01-01 | Naunyn-Schmiedeberg's Archiv f�r Experimentelle Pathologie und Pharmakologie |