6533b870fe1ef96bd12d06b1

RESEARCH PRODUCT

Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity

Carmela Rita BalistreriEgle IncalcaterraMarco CarusoGiuseppina CandoreCalogero CarusoClaudio Franceschi

subject

MaleChemokineReceptors CCR5media_common.quotation_subjectLongevityMyocardial InfarctionInfarctionInflammationRisk FactorsmedicineHumansGenetic Predisposition to DiseaseMyocardial infarctionReceptorSicilyAllelesAgedmedia_commonAged 80 and overInflammationSettore MED/04 - Patologia Generalebiologybusiness.industryLongevityHematologyAtherosclerosismedicine.diseasePathophysiologyCardiovascular DiseasesImmunologybiology.proteinFemaleinfarction longevity CCR5medicine.symptomCC chemokine receptorsbusiness

description

A key component of atherosclerosis is inflammation. So, genes encoding inflammatory or antiinflammatory molecules are good candidates for the risk of cardiovascular diseases (CVD), as acute myocardial infarction (AMI). In this study we demonstrated that genetic variations in CCR5 gene affect atherosclerosis and risk of AMI, hence consenting the attainment of longevity.

yearjournalcountryeditionlanguage
2008-01-01Haematologica
https://doi.org/10.3324/haematol.12239