6533b870fe1ef96bd12d0778

RESEARCH PRODUCT

Diabetes Mellitus and Its Association to the Occurrence of Medication-Related Osteonecrosis of the Jaw

Lukas OlkKeyvan SaghebRoman Kia Rahimi-nedjatAndreas PabstChristian Walter

subject

medicine.medical_specialtyPopulationArticle03 medical and health sciences0302 clinical medicineInternal medicineDiabetes mellitusmedicinediabetes; hyperglycemia; bisphosphonates; denosumab; MR-ONJ; BP-ONJRisk factoreducationGeneral DentistryPathologicalbisphosphonatesAnamnesiseducation.field_of_studyBP-ONJdiabetesbusiness.industrySignificant differencedenosumab030206 dentistrymedicine.diseaseSurgerylcsh:RK1-715Denosumab030220 oncology & carcinogenesislcsh:DentistryMR-ONJhyperglycemiaOsteonecrosis of the jawbusinessmedicine.drug

description

To date there is no consensus on the role of diabetes in the development of medication-related osteonecrosis of the jaws (MR-ONJ). Therefore, this study aimed to investigate the prevalence of diabetes and pathological glucose metabolism in patients with MR-ONJ compared to the general population. All maxillofacial surgery inpatients in one year at our department were investigated regarding diagnosis, anamnesis, medication, and blood glucose readings. 1374 records were analyzed. 35 patients with MR-ONJ were identified. Diabetics accounted for 14.3%. No significant difference in the prevalence of known diabetes was found, except for pathological glucose metabolism in patients with MR-ONJ (p < 0.001). Diabetes does not necessarily promote the onset of MR-ONJ. Therefore, diabetes should not be considered as a standalone risk factor. On the contrary, hyperglycemia as a possible indicator for poorly managed or yet undetected diabetes is associated with MR-ONJ.

yearjournalcountryeditionlanguage
2016-05-31Dentistry Journal; Volume 4; Issue 2; Pages: 17
10.3390/dj4020017https://dx.doi.org/10.3390/dj4020017