6533b870fe1ef96bd12d0834
RESEARCH PRODUCT
Genomic Testing for Human Health and Disease Across the Life Cycle: Applications and Ethical, Legal, and Social Challenges
Gemma A. BilkeyGemma A. BilkeyBelinda L. BurnsEmily P. ColesFaye L. BowmanJohn BeilbyJohn P. BeilbyNicholas S. PachterNicholas S. PachterGareth BaynamGareth BaynamGareth BaynamGareth BaynamGareth BaynamHugh J. S. DawkinsHugh J. S. DawkinsHugh J. S. DawkinsHugh J. S. DawkinsKristen J. NowakKristen J. NowakKristen J. NowakTarun S. WeeramanthriTarun S. Weeramanthrisubject
Computer scienceclinical utilityReviewDiseasegenomic testingmolecular diagnostics03 medical and health sciencesHuman health0302 clinical medicineHealthcare deliverygenetic diseaseInformed consentHealth caregenomics030212 general & internal medicineScope (project management)business.industrylcsh:Public aspects of medicine030503 health policy & servicesPublic Health Environmental and Occupational Healthhealthcarelcsh:RA1-1270Genomic technologyEngineering ethicsPublic Healthgenomic dataPersonalized medicine0305 other medical sciencebusinessdescription
The expanding use of genomic technologies encompasses all phases of life, from the embryo to the elderly, and even the posthumous phase. In this paper, we present the spectrum of genomic healthcare applications, and describe their scope and challenges at different stages of the life cycle. The integration of genomic technology into healthcare presents unique ethical issues that challenge traditional aspects of healthcare delivery. These challenges include the different definitions of utility as applied to genomic information; the particular characteristics of genetic data that influence how it might be protected, used and shared; and the difficulties applying existing models of informed consent, and how new consent models might be needed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-03-01 | Frontiers in Public Health |