6533b871fe1ef96bd12d0e7d
RESEARCH PRODUCT
Autoimmune Lebererkrankungen: Diagnostik und Therapie
E.m. BayerAw LohseChristoph SchrammStephan Kanzlersubject
Hepatitismedicine.medical_specialtyCirrhosismedicine.diagnostic_testbusiness.industrymedicine.medical_treatmentGastroenterologyAutoimmune hepatitisLiver transplantationmedicine.diseaseGastroenterologydigestive system diseasesPrimary sclerosing cholangitisLiver diseasePrimary biliary cirrhosisInternal medicineImmunologyMedicinebusinessLiver function testsdescription
Autoimmune Hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and overlap syndromes of these three disease entities are regarded as autoimmune liver diseases. These conditions are important differential diagnoses of elevated liver function tests as about 10 % of liver transplantations in Europe and North America are for these indications. The diagnosis is often difficult but can be facilitated by sequential measurement of relevant autoantibodies, exclusion of other liver disease, ultrasound, ERCP and liver histology. In AIH immunosuppressive therapy has been shown to prevent or stop the development of cirrhosis and improve the prognosis of the patients decisively. In other autoimmune liver diseases this evidence is missing making individual therapeutic decisions necessary. Ursodesoxycholic acid (UDCA) seems to slow disease progression in particular in early stages of PBC.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-02-02 | Zeitschrift für Gastroenterologie |