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RESEARCH PRODUCT
Nitric oxide metabolites (nitrite and nitrate) in young patients with recent acute myocardial infarction
Rosalia Lo PrestiVincenzo CalandrinoMaria MontanaCaterina CarolloGregorio CaimiMarco CarusoAnna Cataniasubject
AdultMalecardiovascular risk factorsmedicine.medical_specialtyPhysiologyCardiovascular risk factorsMyocardial Infarctionacute myocardial infarctionNitric oxidechemistry.chemical_compoundNitrateRisk FactorsnitratePhysiology (medical)Internal medicinemedicineHumansMyocardial infarctionNitritenitriteNitritesInflammationNitratesbusiness.industryNitric oxideHematologymedicine.diseaseControl subjectsPathophysiologychemistryPlasma concentrationCardiologyFemaleCardiology and Cardiovascular Medicinebusinessdescription
Nitric oxide (NO) has a role in the pathophysiology of acute and chronic cardiovascular events. We studied the plasma concentration of NO stable end products (nitrite and nitrate - NO x ) in 43 patients aged <46 years, with recent acute myocardial infarction (AMI). The evaluation was effected at the initial stage, after 3 and 12 months. We subdivided the patients into subgroups according to the number of the main cardiovascular risk factors and to the extent of coronary disease. In the whole group the NO x concentration was initially increased and progressively decreased after 3 and 12 months, remaining at both times significantly higher than in control subjects. The patients with more risk factors had a significantly higher NO x concentration. In conclusion, the persisting high NO x concentration in AMI patients is the expression of a prolonged inflammatory condition and is significantly influenced by the simultaneous presence of several cardiovascular risk factors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-11-26 | Clinical Hemorheology and Microcirculation |