6533b871fe1ef96bd12d1026

RESEARCH PRODUCT

Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Michel BouvierStephen J LolaitHans H. ZinggMark WheatleyGilles GuillonMelvyn SoloffTadashi KimuraClaudine Serradeil-le GalBice ChiniAnne-marie O'carrollGerald GimplJoseph G. VerbalisD. G. BichetMark A. KnepperMaurice ManningBernard Mouillac

subject

endocrine systemVasopressinChemistryNeurophysin INeuropeptideNeurophysinsPharmacologyOxytocin receptorOxytocinNeurophysin IImedicineReceptorhormones hormone substitutes and hormone antagonistsmedicine.drug

description

Vasopressin (AVP) and oxytocin (OT) receptors (nomenclature as recommended by NC-IUPHAR [92]) are activated by the endogenous cyclic nonapeptides vasopressin and oxytocin. These peptides are derived from precursors which also produce neurophysins (neurophysin I for oxytocin; neurophysin II for vasopressin). Vasopressin and oxytocin differ at only 2 amino acids (positions 3 and 8). There are metabolites of these neuropeptides that may be biologically active [67].

yearjournalcountryeditionlanguage
2019-09-16IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/f66/2019.4