6533b871fe1ef96bd12d1875
RESEARCH PRODUCT
Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells
Girts SalmsAleksandrs GrisulonoksAndrejs SkagersVadims KlimecsArnis AbolinsJanis LocsIlze ŠAlmaInese Cakstinasubject
Bone mineralmedicine.medical_specialtyMaterials scienceMechanical EngineeringOsteoporosisCellMesenchymal stem cell030209 endocrinology & metabolism030206 dentistrymedicine.diseaseBone tissueTransplantation03 medical and health sciences0302 clinical medicineEndocrinologymedicine.anatomical_structureMechanics of MaterialsInternal medicinemedicineGeneral Materials ScienceStem cellBone regenerationdescription
To target areas of the skeletal system which are clinically significant sites is a new strategy as the"local treatment of osteoporosis". Synthetic bioceramics implanted into critical sized bone defect of rats with experimental osteoporosis demonstrateds better effect to bone tissue repair in osteoporosis and/or osteoporosis status. Stem cell transplantation may improve bone mineral density in animal models of osteoporosis. An adequate blood supply of mesenchymal cells (MSCs and osteoprogenitors) is important for efficient bone regeneration. The concentration and quality of MSCs may vary significantly, depending on the individual (especially in older people), the cell obtaining sites and techniques used. Combination of BCP and stem cells are not studied on old experimental animals with double induced osteoporosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-12-01 | Key Engineering Materials |