6533b871fe1ef96bd12d1aa5

RESEARCH PRODUCT

Chemical Reaction Monitoring Using Zero-Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers

Igor V. KoptyugJohn W. BlanchardKirill V. KovtunovDudari B. BuruevaJames EillsRomán Picazo-frutosAntoine GarconDmitry BudkerDmitry Budker

subject

Chemical substanceMaterials scienceHydrogenAnalytical chemistrychemistry.chemical_element010402 general chemistry01 natural sciencesChemical reaction7. Clean energyCatalysisNMR spectroscopyHyperpolarization (physics)Research Articleshyperpolarization010405 organic chemistryReaction MonitoringGeneral MedicineGeneral ChemistryNuclear magnetic resonance spectroscopyequipment and suppliesMagnetic susceptibility0104 chemical sciencesMagnetic fieldzero-fieldchemistryddc:540Electromagnetic shieldingResearch Article

description

Abstract We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero‐field nuclear magnetic resonance spectroscopy. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two‐step hydrogenation of dimethyl acetylenedicarboxylate with para‐enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero‐field NMR signals ensure that there is no significant signal attenuation arising from shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made of conductive materials while maintaining resolution and chemical specificity.

yearjournalcountryeditionlanguage
2020-04-23
https://doi.org/10.26434/chemrxiv.12168312.v1