6533b871fe1ef96bd12d2562
RESEARCH PRODUCT
Cytogenetic findings in malignant mixed mesodermal tumors of the uterus.
Jose TorresAntonio Llombart-boschCarlos Monteagudo-crespoRosario Gil-bensoConcha López-ginésCarmen Carda-batallasubject
Cancer ResearchPathologymedicine.medical_specialtyUterusHeterologousBiologyMiceGeneticsmedicineHomologous chromosomeAnimalsHumansMolecular BiologyAgedGeneticsChromosome AberrationsMixed Tumor MesodermalCytogeneticsChromosomeKaryotypeMiddle Agedmedicine.diseasePrimary tumormedicine.anatomical_structureIn uteroKaryotypingUterine NeoplasmsFemaleNeoplasm Transplantationdescription
Abstract Cytogenetic analyses of four malignant mixed mesodermal tumors (MMMT) of the uterus are reported, of which one was of the homologous type and three of the heterologous type. Karyotypic analyses were obtained in two cases from original tumors and in two cases from tumors xenotransplanted into nude mice. The karyotype of the homologous MMMT was normal in three different passages of a nude mice xenograft line established from the primary tumor. The heterologous tumors showed normal karyotype in one case and hyperdiploid and near triploid range with extensive numerical and structural rearrangements in two cases. Deletion of chromosome 1 at p32, and deletion of chromosome 11 at q13 were common markers in anomalous cases. The chromosomes most often involved in structural rearrangements were chromosomes 1, 9, 11, 12, 17, and 19. Double minutes, homogeneously staining regions, and telomeric association were also seen.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-12-17 | Cancer genetics and cytogenetics |