0000000000010896

AUTHOR

Jose Torres

0000-0002-1525-1828

High resolution Time of Flight determination based on reconfigurable logic devices for future PET/MR systems

Abstract This contribution shows how to perform Time of Flight (TOF) measurements in PET systems using low-cost Field Programmable Gate Array (FPGA) devices with a resolution better of 100 ps. This is achieved with a proper management of the FPGA internal resources and with an extremely careful device calibration process including both temperature and voltage compensation. Preliminary results are reported.

research product

Installation and commissioning of the TileCal Read-Out Drivers

TileCal is the hadronic tile calorimeter of the ATLAS experiment at LHC/CERN. The main component of the TileCal back-end electronics is the Read-Out Driver (ROD). The ROD system is placed between the first and the second level trigger and it is the responsible for processing the data gathered by the detector. The principal devices of the RODs are the Digital Signal Processors (DSPs) mounted in the Processing Units (PUs) daughterboards. The architecture and functionality of the RODs are briefly explained. Then, it is presented the ROD system installation in the ATLAS electronics cavern. Currently, the RODs are being used for the detector commissioning. It is detailed the Detector and Verific…

research product

Detector blockbased on arrays of 144 SiPMs and monolithic scintillators: A performane study

[EN] We have developed a detector block composed by a monolithic LYSO scintillator coupled to a custom made 12 12 SiPMs array. The design is mainly focused to applications such as Positron Emission Tomography. The readout electronics is based on 3 identical and scalable Application Specific Integrated Circuits (ASIC). We have determined the main performance of the detector block namely spatial, energy, and time resolution but also the system capability to determine the photon depth of interaction, for different crystal surface treatments. Intrinsic detector spatial resolution values as good as 1.7 mm FWHM and energies of 15% for black painted crystals were measured. & 2014 Elsevier B.V. All…

research product

The optical instrumentation of the ATLAS Tile Calorimeter

The purpose of this Note is to describe the optical assembly procedure called here Optical Instrumentation and the quality tests conducted on the assembled units. Altogether, 65 Barrel (or LB) modules were constructed - including one spare - together with 129 Extended Barrel (EB) modules (including one spare). The LB modules were mechanically assembled at JINR (Dubna, Russia) and transported to CERN, where the optical instrumentation was performed with personnel contributed by several Institutes. The modules composing one of the two Extended Barrels (known as EBA) were mechanically assembled in the USA, and instrumented in two US locations (ANL, U. of Michigan), while the modules of the oth…

research product

DSP Online Algorithms for The ATLAS TileCal Read-Out Drivers

TileCal is the hadronic tile calorimeter of the ATLAS experiment at LHC/CERN. The central element of the back-end system of the TileCal detector is the read-out driver (ROD).The main components of the TileCal ROD are the digital signal processors (DSPs) placed on the processing unit (PU) daughterboards. This paper presents a detailed description of the code developed for the DSPs. The code is divided into two different parts: the first part contains the core functionalities and the second part the reconstruction algorithms. The core acts as an operating system and controls configuration, data reception and transmission and synchronization between front-end data and the timing, trigger and c…

research product

Application of a new wireless instrument to characterize thermal properties of ground coupled heat exchangers

Abstract In this work, we report the design and laboratory test of a new instrument to measure the temperature of the heat transfer fluid along the borehole exchanger (BHE) by autonomous wireless sensor. The instrument consists of a device, which inserts and extracts miniaturized wireless sensors in the borehole with a mechanical subsystem, composed by a circulating pump and two valves. This device transmits to the sensors the acquisition configuration, and downloads the temperature data measured by the sensor along its way through the borehole heat exchanger. Each sensor is included in a sphere of 25 mm diameter and contains a transceiver, a microcontroller, a temperature sensor and a powe…

research product

Testbeam studies of production modules of the ATLAS Tile Calorimeter

We report test beam studies of {11\,\%} of the production ATLAS Tile Calorimeter modules. The modules were equipped with production front-end electronics and all the calibration systems planned for the final detector. The studies used muon, electron and hadron beams ranging in energy from 3~GeV to 350~GeV. Two independent studies showed that the light yield of the calorimeter was $\sim 70$~pe/GeV, exceeding the design goal by {40\,\%}. Electron beams provided a calibration of the modules at the electromagnetic energy scale. Over 200~calorimeter cells the variation of the response was {2.4\,\%}. The linearity with energy was also measured. Muon beams provided an intercalibration of the respo…

research product

Design approach for high efficiency NFC systems with magnetic shielding materials

The performance of a Near Field Communication (NFC) antenna may be diminished when it is placed close to any conductive surface such as a metallic case or a battery. This degradation is caused due to the stray magnetic field created by the eddy currents induced on the surface, which is opposite to the intended field generated by the NFC antenna. One of the first solutions that come to mind to designers when facing this problem is the use of high permeability magnetic shielding based on sintered ferrite sheets. This is a good approach but something that is not generally taken into account is that these materials introduce an additional inductance to the NFC antenna. If the permeability of th…

research product

Analysis of different Sleeve Ferrite Cores Performance according to their Dimensions

Sleeve ferrite core is an EMI suppressor widely used to reduce the conductive and radiated electromagnetic noise in cables. The interconnection of different electronic systems through cables is becoming more difficult due to the hard restrictions related to EMC compliance requirements. Thereby, the research of new solutions able to provide a great attenuation ratio in a wide frequency band is a challenge. This contribution focuses on analyzing and comparing the performance of a novel sleeve ferrite solution based on a nanocrystalline (NC) structure with several materials with different compositions. This component is able to provide a high initial permeability value at the same time that ma…

research product

Novel Wireless Sensor System for Dynamic Characterization of Borehole Heat Exchangers

The design and field test of a novel sensor system based in autonomous wireless sensors to measure the temperature of the heat transfer fluid along a borehole heat exchanger (BHE) is presented. The system, by means of two specials valves, inserts and extracts miniaturized wireless sensors inside the pipes of the borehole, which are carried by the thermal fluid. Each sensor is embedded in a small sphere of just 25 mm diameter and 8 gr weight, containing a transceiver, a microcontroller, a temperature sensor and a power supply. A wireless data processing unit transmits to the sensors the acquisition configuration before the measurements, and also downloads the temperature data measured by the…

research product

Study of a Novel High Permeability Ferrite Sheet Intended for Near Field Communication Systems

The reduction of embedded portable devices involves a magnetic field interference problem when it integrates Near Field Communication (NFC) due to the presence of conductive surfaces such as ground planes, batteries or metallic enclosures. This contribution is focused on analyzing the ability of an innovative magnetic shielding based on flexible sintered ferrite sheets (FSFS) with the aim of improving the performance of that kind of systems. Thereby, a NFC emitter antenna is characterized when it is close to a conductive surface through an electromagnetic (EM) scanner. The EM scanner composed by a matrix of near field probes that make it possible to determine the effectiveness of the FSFS. …

research product

RF Acquisition System Based on μTCA for Testing of High-Gradient Acceleration Cavities

The radio frequency (RF) laboratory hosted in the Corpuscular Physics Institute (IFIC) of the University of Valencia is designed to house a high-power and high-repetition-rate facility to test normal conduction RF accelerator cavities in the S-Band (2.9985 GHz) in order to perform R&D activities related to particle accelerator cavities. The system, which manages the entire process of RF signal generation, data acquisition and closed-loop control of the laboratory, is currently based on a modular and compact PXI platform system. This contribution details the development of a platform with similar features, but which is based on open architecture standards at both the hardware and softwar…

research product

Improving the Efficiency of NFC Systems Through Optimizing the Sintered Ferrite Sheet Thickness Selection

The reduction of embedded portable devices involves a magnetic field interference problem when it integrates near field communication (NFC) due to the presence of conductive surfaces, such as ground planes, batteries, or metallic enclosures. Flexible sintered ferrite sheets (FSFS) represent an interesting shielding solution to prevent electromagnetic interferences problems related to NFC, thanks to their ability to control the magnetic flux. The characterization of FSFS effectiveness is analyzed as a function of the sheet thickness in this contribution. This is performed with the aim of determining which is the optimum thickness value to retune an NFC antenna to its original operation frequ…

research product

Algorithms for the ROD DSP of the ATLAS Hadronic Tile Calorimeter

In this paper we present the performance of two algorithms currently running in the Tile Calorimeter Read-Out Driver boards for the commissioning of ATLAS. The first algorithm presented is the so called Optimal Filtering. It reconstructs the deposited energy in the Tile Calorimeter and the arrival time of the data. The second algorithm is the MTag which tags low transverse momentum muons that may escape the ATLAS muon spectrometer first level trigger. Comparisons between online (inside the Read-Out Drivers) and offline implementations are done with an agreement around 99% for the reconstruction of the amplitude using the Optimal Filtering algorithm and a coincidende of 93% between the offli…

research product

Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2'-deoxyguanosine in advanced epithelial ovarian carcinoma of a Spanish community.

In the present study, we describe the changes of antioxidant enzyme activities and other oxidative stress-related parameters in a mediterranean cohort of women affected with epithelial ovarian carcinoma (EOC). For that purpose, the most representative enzymatic activities, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the oxidized/reduced glutathione (GSSG/GSH) ratio have been analyzed in tumor tissue biopsies and compared with the normal tissue of the same patient. As oxidation products, the levels of malondialdehyde (MDA) as an indication of lipid peroxidation, and the DNA damaged base 8-oxo-2'-deoxyguanosine (8-oxo-dG) have been also measured. Ad…

research product

Wireless Sensor Network for Monitoring Thermal Evolution of the Fluid Traveling inside Ground Heat Exchangers

Ground-Coupled Heat Pump (GCHP) systems are an attractive choice of system for heating and cooling buildings (Genchi, 2002; Sanner, 2003; Omer, 2008; Urchueguia, 2008). By comparison with standard technologies, these heat pumps offer competitive levels of comfort, reduced noise levels, lower greenhouse gas emissions, and reasonable environmental safety. Furthermore, their electrical consumption and maintenance requirements are lower than those required by conventional systems and, consequently, they have a lower annual operating cost (Lund, 2000). Ground source systems are recognized by the U.S. Environmental Protection Agency as being among the most efficient and comfortable heating and co…

research product

Determination of Core Size Dependency on the EMI Suppression in Cable Ferrites

Electromagnetic Compatibility (EMC) engineering should be approached via the systems approach, considering EMC throughout the design to anticipate possible electromagnetic interferences (EMI) problems. Nevertheless, an EMI source may appear when the designed device is supplied via an external power system or it is connected to another device to communicate to it. In these both cases, the cables or interfaces that interconnect the systems could represent the EMI source. Thereby, one of the most common techniques for reducing EMI in cables is the application of an EMI suppressor such as sleeve ferrite cores to them. The advantage of this solution is that it does not involve redesign the elect…

research product

A VLSI for deskewing and fault tolerance in LVDS links

The device presented at this work is a switch implemented in a 0.35 mum CMOS process for compensating the skew which affects parallel data signal transmissions and for providing fault tolerance in large scale scalable systems, for instance used in trigger farms for high energy physics experiments. The SWIFT chip (SWItch for Fault Tolerance) is part of a cluster built around commercially components which has been inspired by the LHCb experiment. The skew is extremely important because it directly affects the sample window available to the receiver logic and either forces to use quality and expensive cables in order to minimize its effects or reduces the maximum signal transmission range or d…

research product

Timing results using an FPGA-based TDC with large arrays of 144 SiPMs

Silicon photomultipliers (SiPMs) have become an alternative to traditional tubes due to several features. However, their implementation to form large arrays is still a challenge especially due to their relatively high intrinsic noise, depending on the chosen readout. In this contribution, two modules composed of SiPMs with an area of roughly mm mm are used in coincidence. Coincidence resolving time (CRT) results with a field-programmable gate array, in combination with a time to digital converter, are shown as a function of both the sensor bias voltage and the digitizer threshold. The dependence of the CRT on the sensor matrix temperature, the amount of SiPM active area and the crystal type…

research product

Characterization of electromagnetic noise suppression sheet for aerospace applications

Electromagnetic noise suppression sheets based on absorber materials can be an interesting solution to reduce or suppress noise emissions at a high-frequency region that may cause complex EMI problems. These materials usually are characterized by their permeability but their performance also depend on other factors such as dimension, geometry, thickness or noise source kind. Three experimental methods are proposed in order to characterize absorber sheets in different kind of applications taking into account the last factors. These setups make it possible to test several samples with different characteristics and to analyse the absorption capacity in applications with transmission line probl…

research product

Signal integrity studies at optical multiplexer board for TileCal system

6 pages.-- ISI Article Identifier: 000253651800006

research product

The ATLAS hadronic tile calorimeter: From construction toward-physics

ATLAS; The Tile Calorimeter, which constitutes the central section of the ATLAS hadronic calorimeter, is a non-compensating sampling device made of iron and scintillating tiles. The construction phase of the calorimeter is nearly complete, and most of the effort now is directed toward the final assembly and commissioning in the underground experimental hall. The layout of the calorimeter and the tasks carried out during construction are described, first with a brief reminder of the requirements that drove the calorimeter design. During the last few years a comprehensive test-beam program has been followed in order to establish the calorimeter electromagnetic energy scale, to study its unifo…

research product

Evaluation of a commercial APD array (Avalanche PhotoDiode) for a readout detector in a hadrontherapy beam characterization application

The aim of the present work is the characterization of the S8898–128–02 Avalanche PhotoDiode array (APDs) from Hamamatsu Photonics. This work includes the implementation of a readout system as well as electronic noise estimation in APDs under several conditions varying integration times and clock frequencies.

research product

Design and Study of a Wide-Band Printed Circuit Board Near-Field Probe

Magnetic near-field probes (NFP) represent a suitable tool to measure the magnetic field level from a small electromagnetic interference (EMI) source. This kind of antenna is useful as a magnetic field probe for pre-compliance EMC measurements or debugging tasks since the user can scan a printed circuit board (PCB) looking for locations with strong magnetic fields. When a strong H-field point is found, the designer should check the PCB layout and components placement in that area to detect if this could result in an EMI source. This contribution focuses on analyzing the performance of an easy to build and low-cost H-field NFP designed and manufactured using a standard PCB stack-up. Thereby,…

research product

Development of the optical multiplexer board prototype for data acquisition in TileCal experiment

The optical multiplexer board is one of the elements present in the read out chain of the tile calorimeter in ATLAS experiment. Due to radiation effects, two optical fibers with the same data come out from the front end boards to this board, which has to decide in real time which one carries good data and pass them to the read out driver motherboard for processing. This paper describes the design and tests of the first prototype, implemented as a 6U VME64x slave module, including both hardware and firmware aspects. In this last, algorithms for cyclic redundancy code checking are used to make the decision. Besides, the board may be used as a data injector for testing purposes of the read out…

research product

Transmission Attenuation Power Ratio Analysis of Flexible Electromagnetic Absorber Sheets Combined with a Metal Layer.

Electromagnetic noise absorber sheets have become a solution for solving complex electromagnetic interference (EMI) problems due to their high magnetic losses. This contribution is focused on characterizing a novel structure that is based on an absorber film with a metal layer attached on its top side. Two different absorber compositions were combined with Al and Cu metal layers in order to study the improvement on the performance of these structures, depending on the complex permeability, absorber film thickness, and type of metal. The transmission attenuation power ratio of the absorber films is analyzed and compared to the performance of absorber and metal structures. The measurement pro…

research product

Extraction of thermal characteristics of surrounding geological layers of a geothermal heat exchanger by 3D numerical simulations

Ground thermal conductivity and borehole thermal resistance are key parameters for the design of closed Ground-Source Heat Pump (GSHP) systems. The standard method to determine these parameters is the Thermal Response Test (TRT). This test analyses the ground thermal response to a constant heat power injection or extraction by measuring inlet and outlet temperatures of the fluid at the top of the borehole heat exchanger. These data are commonly evaluated by models considering the ground being homogeneous and isotropic. This approach estimates an effective ground thermal conductivity representing an average of the thermal conductivity of the different layers crossed by perforation. In order …

research product

Time of flight measurements based on FPGA using a breast dedicated PET

In this work the implementation of a Time-to-Digital Converter (TDC) using a Nutt delay line FPGA-based and applied on a Positron Emission Tomography (PET) device is going to be presented in order to check the system’s suitability for Time of Flight (TOF) measurements. In recent years, FPGAs have shown great advantages for precise time measurements in PET. The architecture employed for these measurements is described in detail. The system developed was tested on a dedicated breast PET prototype, composed of LYSO crystals and Positive Sensitive Photomultipliers (PSPMTs). Two distinct experiments were carried out for this purpose. In the first test, system linearity was evaluated in order to …

research product

Performance Study of Split Ferrite Cores Designed for EMI Suppression on Cables

The ideal procedure to start designing an electronic device is to consider the electromagnetic compatibility (EMC) from the beginning. Even so, EMC problems can appear afterward, especially when the designed system is interconnected with external devices. Thereby, electromagnetic interferences (EMIs) could be transmitted to our device from power cables that interconnect it with an external power source or are connected to another system to establish wired communication. The application of an EMI suppressor such as a sleeve core that encircles the cables is a widely used technique to attenuate EM disturbances. This contribution is focused on the characterization of a variation of this cable …

research product

Position sensitive photosensors based on SiPM arrays

research product

Time of flight measurements based on FPGA and SiPMs for PET–MR

Coincidence time measurements with SiPMs have shown to be suitable for PET/MR systems. The present study is based on 3 x 3 mm(2) SiPMs, LSO crystals and a conditioning signal electronic circuit. A Constant Fraction Discriminator (CFD) is used to digitalize the signals and a TDC FPGA-implemented is employed for fine time measurements. TDC capability allows processing the arrival of multiple events simultaneously, measuring times under 100 ps. The complete set-up for time measurements results on a resolution of 892 +/- 41 ps for a pair of detectors. The details of such implementation are exposed and the trade-offs of each configuration are discussed. (C) 2013 Elsevier By, All rights reserved,

research product

Analysis of EMI Shielding Effectiveness for plastic fiber composites in the 5G sub-6 GHz band

The study and modeling of EMC are becoming more critical than ever due to the ubiquitous presence of electronic circuits in all aspects of our lives. Specifically, it is crucial to extend these studies to the new frequencies that, in a few years, will be a reality in modern telecommunications systems, such as 5G and its derived technologies. A specific critical field where the proper EMI shielding has been ensured to avoid EMC problems is the electric autonomous vehicles (EAVs). The huge number of electronics systems in new vehicles will dramatically extend the demands on the EMI shielding solutions used to attenuate the radiated emissions that could affect circuits in the vehicle. Metals o…

research product

The Optical Multiplexer Board for the ATLAS Hadronic Tile Calorimeter

This paper presents the architecture and the status of the optical multiplexer board (OMB) for the ATLAS/LHC tile hadronic calorimeter (TileCal). This board will analyze the front-end data CRC to prevent bit and burst errors produced by radiation. Besides, due to its position within the data acquisition chain it will be used to emulate front-end data for tests. The first two prototypes of the final OMB 9U version have been produced at CERN. Detailed design issues and manufacturing features of these prototypes are described. These prototypes are being validated while firmware developments are being implemented in the programmable devices of the board.

research product

Development of the Optical Multiplexer Board Prototype for Data Acquisition in the TileCal System

This paper describes the development of the optical multiplexer board (OMB), also known as PreROD board, for the TileCal readout system in the ATLAS experiment. The aim of this board is to overcome the problems that may arise in the integrity of data due to radiation effects. The solution adopted has been to add redundancy to data transmission and so two optical fibers with the same data come out from the detector front end boards. The OMB has to decide in real time which fiber, eventually, carries data with no errors switching it to the output link connected to the read out driver (ROD) motherboard where data processing takes place. Besides, the board may be also used as a data injector fo…

research product

Optimization of a Time-to-Digital Converter and a coincidence map algorithm for TOF-PET applications

This contribution describes the optimization of a multichannel high resolution Time-to-Digital Converter (TDC) in a Field-Programmable Gate Array (FPGA) initially capable of obtaining time resolutions below 100ps for multiple channels. Due to its fast propagation capability it has taken advantage of the FPGA internal carry logic for accurate time measurements. Furthermore, the implementation of the TDC has been performed in different clock regions and tested with different frequencies as well, achieving improvements of up to 50% for a pair of channels. Moreover, since the TDC is potentially going to be used in a trigger system for Positron Emission Tomography (PET), the algorithm for coinci…

research product

Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter

The response of pions and protons in the energy range of 20–180 GeV, produced at CERN's SPS H8 test-beam line in the ATLAS iron–scintillator Tile hadron calorimeter, has been measured. The test-beam configuration allowed the measurement of the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It was found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion-to-proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion-indu…

research product

Characterization of Different Cable Ferrite Materials to Reduce the Electromagnetic Noise in the 2–150 kHz Frequency Range

The gap of standardization for conducted and field coupled electromagnetic interferences (EMI) in the 2–150 kHz frequency range can lead to Electromagnetic Compatibility (EMC) problems. This is caused by power systems such as Pulse Width Modulation (PWM) controlled rectifiers, photovoltaic inverters or charging battery units in electric vehicles. This is a very important frequency spectral due to interferences generated in a wide range of devices and, specifically, communication problems in the new technologies and devices incorporated to the traditional grid to convert it into a Smart Grid. Consequently, it is necessary to provide new solutions to attenuate this kind of interference, which…

research product

Characterization of Different Cable Ferrite Materials to Reduce the Electromagnetic Noise in the 2–150 kHz Frequency Range

The gap of standardization for conducted and field coupled electromagnetic interferences (EMI) in the 2–150 kHz frequency range can lead to Electromagnetic Compatibility (EMC) problems. This is caused by power systems such as Pulse Width Modulation (PWM) controlled rectifiers, photovoltaic inverters or charging battery units in electric vehicles. This is a very important frequency spectral due to interferences generated in a wide range of devices and, specifically, communication problems in the new technologies and devices incorporated to the traditional grid to convert it into a Smart Grid. Consequently, it is necessary to provide new solutions to attenuate this kind of interference, which…

research product

Mechanical construction and installation of the ATLAS tile calorimeter

This paper summarises the mechanical construction andinstallation of the Tile Calorimeter for the ATLASexperiment at the Large Hadron Collider in CERN, Switzerland. The TileCalorimeter is a sampling calorimeter using scintillator as the sensitivedetector and steel as the absorber and covers the central region of the ATLASexperiment up to pseudorapidities ±1.7. The mechanical construction ofthe Tile Calorimeter occurred over a periodof about 10 years beginning in 1995 with the completionof the Technical Design Report and ending in 2006 with the installationof the final module in the ATLAS cavern. Duringthis period approximately 2600 metric tons of steel were transformedinto a laminated struc…

research product

The ATLAS tile calorimeter ROD injector and multiplexer board

Abstract The ATLAS Tile Calorimeter is a sampling detector composed by cells made of iron-scintillator tiles. The calorimeter cell signals are digitized in the front-end electronics and transmitted to the Read-Out Drivers (RODs) at the first level trigger rate. The ROD receives triggered data from up to 9856 channels and provides the energy, phase and quality factor of the signals to the second level trigger. The back-end electronics is divided into four partitions containing eight RODs each. Therefore, a total of 32 RODs are used to process and transmit the data of the TileCal detector. In order to emulate the detector signals in the production and commissioning of ROD modules a board call…

research product

High-resolution multichannel Time-to-Digital Converter core implemented in FPGA for ToF measurements in SiPM-PET

In this contribution, Coincidence Resolving Time (CRT) results with the developed multichannel FPGA-TDC are showed as a function of different configurations for both, the sensor bias voltage and the digitizer threshold. The dependence of the CRT with the sensor matrix temperature, the amount of SiPM active area and the crystal type are also analyzed. Preliminary measurements carried out with a crystal array of 2 mm pixel size and 10 mm height have shown time resolutions for the entire 144 SiPM two-detectors ensemble as good as 800 ps.

research product

Cytogenetic findings in malignant mixed mesodermal tumors of the uterus.

Abstract Cytogenetic analyses of four malignant mixed mesodermal tumors (MMMT) of the uterus are reported, of which one was of the homologous type and three of the heterologous type. Karyotypic analyses were obtained in two cases from original tumors and in two cases from tumors xenotransplanted into nude mice. The karyotype of the homologous MMMT was normal in three different passages of a nude mice xenograft line established from the primary tumor. The heterologous tumors showed normal karyotype in one case and hyperdiploid and near triploid range with extensive numerical and structural rearrangements in two cases. Deletion of chromosome 1 at p32, and deletion of chromosome 11 at q13 were…

research product