Metabolic changes in the rat liver during pregnancy

6533b871fe1ef96bd12d25e0

RESEARCH PRODUCT

Metabolic changes in the rat liver during pregnancy

M. Höckel R. Rosskopf J. M. Klug P. Brockerhoff K.h. Schicketanz G.h. Rathgen

subject

medicine.medical_specialty Metabolite Citric Acid Cycle chemistry.chemical_compound Pregnancy Internal medicine medicine Animals chemistry.chemical_classification Fetus Pregnancy business.industry Glutamate receptor Tricarboxylic Acids Obstetrics and Gynecology Fasting General Medicine Metabolism medicine.disease Rats Citric acid cycle Enzyme Endocrinology Liver chemistry Gestation Female business

description

During pregnancy the rat liver shows alterations in metabolism which apparently do not to occur in the non-pregnant animal. In our study, the following metabolite concentrations and enzyme activities in the liver of pregnant and non-pregnant rats were measured after fasting periods of 6 and 12 h: malate, fumarate, isocitrate, alpha-keto-glutarate, glutamate, malate-dehydrogenase, fumarate-hydratase, glutamate-dehydrogenase, isocitrate-dehydrogenase, aspartate-aminotransferase and after 12 h fast, the concentrations of acetyl coenzyme A and citrate. These results are discussed with regard to their possible importance for the maternal and fetal energy supply.

year	journal	country	edition	language
1983-09-01	Archives of Gynecology

https://doi.org/10.1007/bf02133798

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