6533b872fe1ef96bd12d2e86
RESEARCH PRODUCT
Effects of a preparation containing a standardized ginseng extract combined with trace elements and multivitamins against hepatotoxin-induced chronic liver disease in the elderly
Pier Maria BattezzatiMassimo ZuinD. RiebenfeldM. PoddaM. Camisascasubject
MaleGinsenosidesmedicine.medical_treatment030204 cardiovascular system & hematologyPharmacologyChronic liver diseaseBiochemistrylaw.inventionGinsengRandom Allocation0302 clinical medicineRandomized controlled triallawClinical Trials as TopicLiver DiseasesHepatotoxinGeneral MedicineVitaminsgamma-GlutamyltransferaseMiddle AgedZincLiver030220 oncology & carcinogenesisDrug Therapy CombinationFemaleChemical and Drug Induced Liver Injurymedicine.medical_specialtyPanaxPlaceboBile Acids and Salts03 medical and health sciencesPharmacotherapyDouble-Blind MethodInternal medicinemedicineHumansAgedChemotherapyPlants Medicinalbusiness.industryBiochemistry (medical)Cell BiologySaponinsmedicine.diseaseDietary FatsTrace ElementsEndocrinologyChronic DiseaseLiver functionbusinessdescription
A preparation containing a standardized ginseng extract which has been shown to exert anti-hepatotoxic activity in vitro, combined with trace elements and multi-vitamins was compared to placebo in 24 elderly out-patients with toxin-induced (alcohol and drugs) chronic liver disease in order to evaluate its effect on liver function. Each patient was blindly treated either with the preparation containing ginseng extract or placebo for 12 weeks. The preparation containing ginseng extract significantly modified bromsulphthalein retention and blood zinc levels when compared to pre-treatment levels and to placebo. Serum bile acids, and γ-glutamyl transpeptidase before and after a fatty meal were significantly reduced after treatment with the test preparation and not with placebo. When the two treatment groups were compared, however, no significant difference in these parameters was observed. These results suggest that treatment with the preparation containing ginseng extract could improve the detoxifying activity of the liver in elderly patients with toxin-induced chronic liver disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-09-01 |