6533b872fe1ef96bd12d3046
RESEARCH PRODUCT
The influence of lorazepam medication upon the transfer properties of the brain during sleep in man
J. B. AldenhoffP. WagnerJoachim Röschkesubject
AdultMalemedicine.medical_specialtyPhotic StimulationPolysomnographyPolysomnographyAudiologyLorazepammedicineHumansPharmacology (medical)Spectral analysisBiological PsychiatryPharmacologyAnalysis of VarianceSleep Stagesmedicine.diagnostic_testInformation processingBrainSignal Processing Computer-AssistedLorazepamSleep in non-human animalsPsychiatry and Mental healthAcoustic StimulationNeurologyAnesthesiaEvoked Potentials AuditoryEvoked Potentials VisualNeurology (clinical)Analysis of varianceSleepPsychologyPhotic Stimulationmedicine.drugdescription
In order to get better insight into the principles of information processing by the brain during sleep and its alterations under the influence of drugs we applied some tools from linear system theory to sleep EEG data. We investigated late components of auditory and visually evoked potentials (AEPs and VEPs) during different sleep stages and calculated from these the so-called amplitude-frequency characteristics (AFC). The main advantage of this analysis is that it enables one to detect functional differences during different sleep stages. This information can hardly be obtained by conventional spectral analysis. The result of our investigation was that the transfer properties of the brain during sleep were extremely different and that lorazepam medication not only resulted in quantitative alterations of the sleep profile but mainly in highly significant alterations of the functional properties of sleep.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-03-01 | European Neuropsychopharmacology |