6533b872fe1ef96bd12d36a4
RESEARCH PRODUCT
CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model
Jürgen PodlechNiels A. W. LemmermannNatascha K. A. GrzimekKai A. KroppRafaela HoltappelsMatthias J. ReddehaseChristof K. Seckertsubject
HepatitisAdrenalitisEffectormedicine.medical_treatmentBone marrow failureImmunotherapyBiologymedicine.diseaseAcquired immune systemVirologyImmune systemImmunologymedicineCytotoxic T celldescription
Publisher Summary Cytomegaloviruses (CMVs) are conditional pathogens that are strictly species specific and are usually well controlled in their respective mammalian hosts by the effector mechanisms of both innate and adaptive immunity. Human CMV (hCMV) is mostly acquired perinatally as well as in early childhood and is transmitted, for instance, through breast milk and saliva. Whilst the immune response in an immunocompetent host prevents an overt CMV disease and rapidly terminates the productive acute infection, viral genome is maintained in most tissues for the life span of the infected host in a state known as viral latency. Latency implies that infectious virions are no longer produced so that the host is no longer infectious. Furthermore, CMV diseases with multiple organ manifestations such as interstitial pneumonia, hepatitis, adrenalitis, gastrointestinal disease and bone marrow failure result from primary or recurrent infection of the immunocompromised or immunologically immature host. The chapter also describes murine CMV.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |