6533b872fe1ef96bd12d3726

RESEARCH PRODUCT

Zum metabolismus von dialkyldithiocarbamaten

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Abstract Metabolism dialkyldithiocarbamates. I. Determination of amines using a reaction with isocyanates followed by gas chromatographic identification of the urea derivatives formed. N,N′-Di- and N,N′,N′-trisubstituted areas, formed by the reaction of amines with isocyanates, e.g. tert. -butyl isocyanate or 3-trifluoromethylphenyl isocyanate, are useful derivatives for the gas chromatographic analysis of primary and secondary amines. The separation is carried out at temperatures between 70 and 130° on liquid phases such as silicone OV-101 and silicone OV-17. With nitrogen and electron capture detectors the detection limit is 10 10 g. Trace analysis of simple primary and secondary amines is important for the study of the metabolism of dialkyl dithiocarbamate fungicides or urea herbicides. Since secondary amines are considered to be potential precursors of cancerogenic nitrosamines their analysis is also of great importance.