6533b872fe1ef96bd12d3818
RESEARCH PRODUCT
Highly antiproliferative neutral Ru(ii)-arene phosphine complexes
Cédric BalanEwen BodioFlorian ChotardAli BettaiebAli BettaiebLucile DondaineLucile DondaineLucile DondaineCatherine PaulCatherine PaulPierre Le Gendresubject
010405 organic chemistrychemistry.chemical_elementCancerGeneral Chemistry010402 general chemistrymedicine.disease01 natural sciencesMedicinal chemistryCatalysis0104 chemical sciencesRutheniumchemistry.chemical_compoundchemistryMaterials ChemistrymedicinePhosphinedescription
Six ruthenium(II)- and four gold(I)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(II) complexes displayed an IC50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 | New Journal of Chemistry |