6533b872fe1ef96bd12d38c2
RESEARCH PRODUCT
CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer.
Brendon J. CoventryJ Mortonsubject
AdultCancer ResearchCellular immunityPathologymedicine.medical_specialtyMammary glandBreast NeoplasmsCD1asurvivalAntigens CD1Breast cancerbreast cancerPredictive Value of Testsmental disordersmedicineHumansskin and connective tissue diseasesAntigen-presenting cellLetter to the EditorSurvival analysisAgedAged 80 and overintegumentary systembusiness.industryMolecular and Cellular PathologyCancerDendritic cellDendritic CellsDuctal carcinomaMiddle Agedmedicine.diseasePrognosisSurvival Analysismedicine.anatomical_structureOncologyCancer researchFemalebusinessdescription
Infiltrating CD1a(+) dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histological grade, lympho-vascular invasion, the KI-67 (MIB-1) fraction and the Nottingham Prognostic Index (NPI) were also compared. A total of 48 breast cancer patients were followed from the time of surgery and CD1a density analysis for 5 years or until death. Our data set validated previous studies, which show a relationship between survival and the NPI (P0.001), tumour size (P0.01) and lymph node status (P0.05). Although more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, this failed to reach statistical significance at the P=0.05 level. Analysis at 10 years postsurgery is required to investigate the association further.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-07-01 | British journal of cancer |