6533b872fe1ef96bd12d4068

RESEARCH PRODUCT

�ber die Wirkung von Apurins�ure und Apyrimidins�ure auf die enzymatische Desoxyribonukleins�ure-(DNA-) Synthese in vitro

B. Heicke

subject

Pharmacologychemistry.chemical_classificationPurinePyrimidinebiologyDNA polymeraseGeneral MedicineMolecular biologyIn vitrochemistry.chemical_compoundEnzymechemistryBiochemistryApyrimidinic acidbiology.proteinApurinic AcidDNA

description

The effect of chemically modified deoxyribonucleic acid (DNA) on enzymatic DNA-synthesis in vitro has been investigated with analogues of DNA prepared without either purine bases (apurinic acid, APA) or pyrimidine bases (apyrimidinic acid, APyA). DNA-synthesis in vitro was studied with the deoxynucleotide polymerizing enzymes purified from calf thymus (replicative and terminal deoxynucleotidyltransferase respectively).

https://doi.org/10.1007/bf00997648