6533b872fe1ef96bd12d4174

RESEARCH PRODUCT

Opioid Poorly-Responsive Cancer Pain. Part 1

Russell K. PortenoySebastiano Mercadante

subject

Palliative carebusiness.industryAnalgesicCancerBioinformaticsmedicine.diseasePain ladderAnesthesiology and Pain MedicineNociceptionOpioidAnesthesiaNeuropathic painmedicineNeurology (clinical)Cancer painbusinessGeneral Nursingmedicine.drug

description

Pain that is poorly responsive to opioid analgesics is challenging for physicians who deal with cancer patients. Numerous factors may influence analgesic response during the course of the illness. These include changing nociception associated with disease progression, the appearance of intractable side effects, the development of tolerance, the presence of neuropathic pain, the temporal pattern, the effects produced by the production of opioid metabolites, and many others. These factors influence the delicate balance between pain relief and opioid toxicity that must be achieved in cancer patients with pain.

yearjournalcountryeditionlanguage
2001-02-01Journal of Pain and Symptom Management
https://doi.org/10.1016/s0885-3924(00)00228-1