6533b872fe1ef96bd12d43ec

RESEARCH PRODUCT

Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells.

Maria CorreiaMarie Aleth Lacaille-duboisGhezala GaidiHildebert WagnerBruno ChauffertJean-luc Beltramo

subject

Cell SurvivalSaponinPharmaceutical SciencePlant RootsFucoseAnalytical Chemistrychemistry.chemical_compoundStructure-Activity RelationshipTriterpeneDrug DiscoverymedicineMoietyHumansOleanolic AcidCytotoxicitySilenePlatinumPharmacologychemistry.chemical_classificationCisplatinDose-Response Relationship DrugPlant ExtractsOrganic ChemistryGlycosideBiological activityDrug SynergismSaponinsTriterpenesComplementary and alternative medicinechemistryBiochemistryMolecular Medicinelipids (amino acids peptides and proteins)CisplatinHT29 Cellsmedicine.drug

description

The triterpene saponins jenisseensosides A, B, C, D were found to increase the accumulation and cytotoxicity of the anticancer agent cisplatin in human colon tumor cells. These compounds are glycosides of quillaic acid whose fucose residue was acylated by a trans- or cis-p methoxycinnamic acid. In contrarst, other saponins derivatives without this acyl moiety were not found to potentiate the accumulation and cytotoxicity of cisplatin. These results suggested the importance of the acyl moiety for activity.

yearjournalcountryeditionlanguage
2002-02-14Planta medica
10.1055/s-2002-19873https://pubmed.ncbi.nlm.nih.gov/11842333