Synthesis and biological activity of novel sialyl-lewisX conjugates

6533b873fe1ef96bd12d4ade

RESEARCH PRODUCT

Synthesis and biological activity of novel sialyl-lewisX conjugates

Gerhand Kretzshmar Wolfgang Schmidt Christoph Hüls Ulrich Sprengard Dirk Dr Seiffge Horst Kunz

subject

Endothelium Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biological activity Adhesion Biochemistry chemistry.chemical_compound Sialyl-Lewis X medicine.anatomical_structure chemistry Biochemistry Drug Discovery medicine Molecular Medicine Potency Cell adhesion Molecular Biology Conjugate

description

Abstract Novel sialyl Lewis X conjugates have been synthesized and evaluated as inhibitors of E- and P-selectin mediated cell adhesion in cell culture assays. The most potent conjugate in the static inhibition assays exhibited a significant and dose-dependent pharmacological potency as inhibitor of the edotoxin-induced leukocyte adhesion to the endothelium of postcapillary venules in rats.

year	journal	country	edition	language
1996-03-01	Bioorganic & Medicinal Chemistry Letters

https://doi.org/10.1016/0960-894x(96)00057-1

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