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RESEARCH PRODUCT
Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study
Laura ManiscalcoMaria Ester LicataAlberto BedogniRodolfo MauceriGiuseppina CampisiEnzo Maria Giuseppe CumboOlga Di FedeFrancesca ToiaA AlbaneseVera PanzarellaGiuseppina Mazzolasubject
MaleGenetics and Molecular Biology (all)medicine.medical_specialtyLongitudinal studyArticle SubjectImmunology and Microbiology (all)medicine.medical_treatmentSettore MED/19 - Chirurgia Plasticalcsh:MedicineLasers Solid-StateSettore MED/08 - Anatomia PatologicaBiochemistryGeneral Biochemistry Genetics and Molecular BiologySettore MED/01 - Statistica Medica03 medical and health sciences0302 clinical medicineSettore MED/28 - Malattie OdontostomatologichemedicineHumansLongitudinal StudiesProspective StudiesSurgical treatmentProspective cohort studyAgedAged 80 and overSurgical approachBiochemistry Genetics and Molecular Biology (all)Bone Density Conservation AgentsDiphosphonatesGeneral Immunology and MicrobiologyPlatelet-Rich Plasmabusiness.industrylcsh:RCancer030206 dentistryGeneral MedicineBisphosphonatemedicine.diseaseSurgery030220 oncology & carcinogenesisPlatelet-rich plasmaClinical StudyBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawbusinessBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)description
Introduction. The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods. We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results. We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. Conclusion. We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients’ lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |