Progression-Free Survival Early Assessment Is a Robust Surrogate Endpoint of Overall Survival in Immunotherapy Trials of Hepatocellular Carcinoma

6533b873fe1ef96bd12d4f68

RESEARCH PRODUCT

Progression-Free Survival Early Assessment Is a Robust Surrogate Endpoint of Overall Survival in Immunotherapy Trials of Hepatocellular Carcinoma

Domenica Matranga Antonio Craxì A. Busacca Calogero Cammà Maria Reig Giacomo Emanuele Maria Rizzo Massimo Attanasio Ciro Celsa Giuseppe Cabibbo Salvatore Battaglia Marco Enea

subject

Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment overall survival lcsh:RC254-282 Article Settore MED/01 - Statistica Medica 03 medical and health sciences 0302 clinical medicine Internal medicine surrogate endpoint medicine Overall survival 030212 general & internal medicine Progression-free survival neoplasms Settore MED/12 - Gastroenterologia business.industry Surrogate endpoint Immunotherapy hepatocellular carcinoma medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Confidence interval Clinical trial Oncology Quartile 030220 oncology & carcinogenesis Hepatocellular carcinoma surrogate endpoints immunotherapy Settore SECS-S/01 - Statistica business progression-free survival

description

Background: Radiology-based outcomes, such as progression-free survival (PFS) and objective response rate (ORR), are used as surrogate endpoints in oncology trials. We aimed to assess the surrogacy relationship of PFS with overall survival (OS) in clinical trials of systemic therapies targeting advanced hepatocellular carcinoma (HCC) by novel meta-regression methods. Methods: A search of databases (PubMed, American Society of Clinical Oncology (ASCO), and European Society for Medical Oncology (ESMO) Meeting Libraries, Clinicaltrials.gov) for trials of systemic therapies for advanced HCC reporting both OS and PFS was performed. Individual patient data were extracted from PFS and OS Kaplan&ndash

year	journal	country	edition	language
2020-12-30	Cancers

10.3390/cancers13010090 http://europepmc.org/articles/PMC7796103

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