6533b873fe1ef96bd12d56fe

RESEARCH PRODUCT

Syntheses and structural study of bile acid amidoalcohols.

Erkki KolehmainenArto ValkonenManu Lahtinen

subject

Models MolecularSpectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyClinical BiochemistryCalorimetryCrystallography X-RayBiochemistryBile Acids and Saltschemistry.chemical_compoundEndocrinologyDifferential scanning calorimetrySide chainMolecular BiologyPharmacologyChloroformCalorimetry Differential ScanningMolecular StructureChemistryOrganic ChemistryNuclear magnetic resonance spectroscopyAmidesThermogravimetryCrystallographyAlcoholsHydrateSingle crystal

description

Preparation, structural and thermoanalytical characterization of fourteen N-hydroxyalkyl 5beta-cholan-24-amides have been performed in this study. The utilized techniques include liquid state and CP-MAS 13C NMR spectroscopy, thermogravimetry, differential scanning calorimetry, and also powder and single crystal X-ray crystallography. The results were discussed and compared to each other and also to previous findings on similar compounds. One pure hydrate form was obtained. Six new single crystal structures were determined, including one hydrated chloroform solvate. Decomposition temperatures were found to correlate with the side chain length, and the number of the hydroxyl groups. The spatial direction of the groups in the steroid skeleton was also found to be relevant in predicting the thermal properties of bile acid amidoalcohols studied.

yearjournalcountryeditionlanguage
2008-11-01Steroids
10.1016/j.steroids.2008.06.006https://pubmed.ncbi.nlm.nih.gov/18638497