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RESEARCH PRODUCT
Relaxation induced by milrinone and rolipram in human penile arteries and veins
Salvador LluchJosé M. VilaGloria SegarraCristina Benlloch DomènechFernando PrietoPascual EmedinaJuan Martínez-leónsubject
AdultMalemedicine.medical_specialtyPhosphodiesterase InhibitorsPhosphodiesterase 3Penile arteryBiologyMuscle Smooth Vascularchemistry.chemical_compoundInternal medicinemedicineHumansDrug InteractionsChildProstaglandin E1RolipramPharmacologyForskolinDose-Response Relationship DrugColforsinMiddle AgedVasodilationEndocrinologymedicine.anatomical_structurechemistryCirculatory systemMilrinoneRolipramMilrinonePenisBlood vesselmedicine.drugdescription
Abstract We studied the relaxant effects of milrinone, an inhibitor of phosphodiesterase 3, and rolipram, an inhibitor of phosphodiesterase 4, on contracted human penile dorsal artery and deep dorsal vein. Vascular rings from 12 multi-organ donors were suspended in organ baths for isometric recording of tension. Both milrinone and rolipram inhibited (100%) the contraction induced by noradrenaline and shifted the relaxation–response curves to the cAMP forming agents prostaglandin E1 and forskolin to the left. The findings indicate that the cAMP pathway appears to be a main determinant of relaxation in human penile vessels.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-05-01 | European Journal of Pharmacology |