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RESEARCH PRODUCT
Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies.
Markus F. NeurathImke Atreyasubject
Oncologymedicine.medical_specialtyColorectal cancermedicine.medical_treatmentT cellAntineoplastic AgentsCancer VaccinesT-Lymphocytes RegulatoryPathogenesisImmune systemLymphocytes Tumor-InfiltratingAntigenAntigens NeoplasmInternal medicinemedicineBiomarkers TumorHumansPharmacology (medical)biologybusiness.industryMacrophagesAntibodies MonoclonalImmunotherapyDendritic Cellsmedicine.diseasePrognosisKiller Cells NaturalCytokinemedicine.anatomical_structureEarly DiagnosisOncologybiology.proteinImmunotherapyAntibodybusinessColorectal NeoplasmsImmunologic Memorydescription
During the last two decades, considerable efforts have been made to improve the prevention, early diagnosis and therapy of colorectal cancer by gaining enhanced insights into disease-specific pathogenesis. Along these lines, tumor-infiltrating immune cells turned out to be critical indicators for an efficient antitumor immune response and the number and type of tumor-infiltrating immune cells determined the resulting tumor prognosis. This review aims to describe the prognostic relevance of the different subsets of tumor-infiltrating immune cells and highlights their specific function in the complex process of immune system-mediated rejection of colorectal cancer cells. Considering the clinical impact of this increased insight into tumor-associated immunology, resulting innovative approaches in the treatment of colorectal cancer are summarized and discussed immunotherapeutic critically.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-04-01 | Expert review of anticancer therapy |