6533b873fe1ef96bd12d5957

RESEARCH PRODUCT

Cytogenetic study of a spindle-cell rhabdomyosarcoma of the parotid gland.

Carmen Carda-batallaAntonio Llombart-boschAntonio Pellı́n-perezRosario Gil-bensoSamuel Navarro-fos

subject

Malecongenital hereditary and neonatal diseases and abnormalitiesCancer Researchmedicine.medical_specialtyPathologyTransplantation HeterologousMice NudeBiologyMyosinsDesminMiceRhabdomyosarcomaGeneticsmedicineAnimalsChromosomes HumanHumansVimentinRhabdomyosarcomaSpindle cell rhabdomyosarcomaChildMolecular BiologyChromosome AberrationsMyoglobinCytogeneticsKaryotypeModal Chromosome NumberAnatomymedicine.diseaseImmunohistochemistryActinsParotid glandParotid Neoplasmsmedicine.anatomical_structureKaryotypingImmunohistochemistrySarcomaNeoplasm Transplantation

description

The cytogenetic analysis of a spindle-cell rhabdomyosarcoma of the parotid gland in a 6-year-old boy is reported. The tumor cells showed an abnormal karyotype with a hypotriploid modal chromosome number and clonal structural rearrangements affecting chromosomes 1, 8, 12, 21, and 22. The tumor karyotype was: 59, XY, -1, -3, -4, -5, -6, +8, +8, +del(8)(q22q24), -9, -10, del(12)(q13), -15, -16, -17, -18, der(21)t(12;21)(p11;p11), -22, der(22)t(1;22)(q12;p11).

yearjournalcountryeditionlanguage
1999-03-24Cancer genetics and cytogenetics
10.1016/s0165-4608(98)00163-0https://pubmed.ncbi.nlm.nih.gov/10087951