6533b874fe1ef96bd12d6096
RESEARCH PRODUCT
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subject
musculoskeletal diseases030203 arthritis & rheumatologyHLA-B27Ankylosing spondylitisHeavy chainPathologymedicine.medical_specialtybusiness.industryTransgeneImmunologyHuman leukocyte antigenDisease pathogenesismedicine.disease3. Good health03 medical and health sciences0302 clinical medicineImmunologymedicineImmunology and AllergyGastrointestinal tissueskin and connective tissue diseasesbusiness030215 immunologydescription
Objectives Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development of Ankylosing Spondylitis and other spondyloarthropathies (SpA), yet the role it plays in disease pathogenesis remains unclear. We investigated the expression of potentially pathogenic non-conventional heavy chain forms (NC) of B27 in synovial and intestinal tissues obtained from SpA patients. We also determined the presence of NC-B27 in joints, lymphoid and gastrointestinal tissue from B27 transgenic (TG1) rats with M.tuberculosis-induced SpA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-06-01 | Journal of Autoimmunity |