Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides.

6533b874fe1ef96bd12d6189

RESEARCH PRODUCT

Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides.

Carmen Formisano Antonella Maggio Cristina Eiroa Maurizio Bruno Sergio Rosselli Carlo Irace Nicola Mascolo Carmen Maffettone

subject

Stereochemistry Elaeoselinum asclepium subsp. meoides Umbelliferae diterpenoids meoidic acid cytotoxic activity Pharmaceutical Science Biology Pharmacognosy Analytical Chemistry chemistry.chemical_compound Cell Line Tumor Drug Discovery otorhinolaryngologic diseases Acetone Cytotoxic T cell Animals Cytotoxicity Cell Proliferation Pharmacology Molecular Structure Organic Chemistry Settore CHIM/06 - Chimica Organica Elaeoselinum asclepium subsp. meoides Antineoplastic Agents Phytogenic Terpenoid Rats Complementary and alternative medicine chemistry Phytochemical Molecular Medicine Diterpene Diterpenes Apiaceae

description

The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid ( 5), new in the literature. The cytotoxic activities of elasclepic acid ( 1), ENT-atis-16-en-19-oic acid ( 2), ent-beyer-15-en-19-oic acid ( 3), ent-kaur-16-en-19-oic acid ( 4) and meoidic acid ( 5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.

year	journal	country	edition	language
2008-08-01	Planta medica

10.1055/s-2008-1074579 https://pubmed.ncbi.nlm.nih.gov/18604778

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