6533b874fe1ef96bd12d618c
RESEARCH PRODUCT
DNA image cytometry
Achim HeintzTheo JungingerRenate HilsHelmut E. GabbertMichael StöckleSiegfried WellekThomas C. Böttgersubject
AdultMalePathologymedicine.medical_specialtyColorectal cancerRectumPolyploidRisk FactorsSurgical oncologymedicineHumansComputer SimulationDNA Image CytometryAgedAged 80 and overAnalysis of VariancePloidiesRectal Neoplasmsbusiness.industryGastroenterologyCancerDNA NeoplasmGeneral MedicineMiddle AgedPrognosismedicine.diseasemedicine.anatomical_structureCancer researchImage CytometryFemaleCytophotometryNeoplasm Recurrence LocalbusinessCytometrydescription
In 68 patients the DNA content of tumor cells was measured by image cytometry after resection of the rectum because of cancer. In the DNA histogram a differentiation between diploid (n = 19), polyploid (n = 24), hypotriploid (n = 17), and hypertriploid (n = 8) tumors was possible. The best relapse-free survival time was found in patients with diploid tumors. The prognosis worsened from polyploid to hypotriploid and was worse in hypertriploid tumors. Testing for a prognostic advantage of diploid over aneuploid tumors without adjustment for additional factors simply by means of the log-rank statistic gave a (one-sided) P of 0.1013. In a multivariate analysis the degree of differentiation turned out most important. Again, an appropriate test for prognostic relevance of DNA content failed to be significant (P = 0.3264).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-05-01 | Diseases of the Colon & Rectum |