Dynamics of CXC group chemokine platelet factor 4 (PF4) plasma levels in non-small cell lung cancer (NSCLC)

6533b874fe1ef96bd12d632c

RESEARCH PRODUCT

Dynamics of CXC group chemokine platelet factor 4 (PF4) plasma levels in non-small cell lung cancer (NSCLC)

Ainis Pirtnieks Simona Donina Jelena Grusina-ujumaza Artjoms Spaks Inta Jaunalksne Dainis Krievins Irina Spaka Aurika Babjoniseva

subject

Medicine(all)Chemokine biology Biochemistry Genetics and Molecular Biology(all)Angiogenesis business.industry lcsh:R lcsh:Medicine Cancer Inflammation General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Poster Presentation Immunology medicine biology.protein Platelet Platelet activation Bone marrow medicine.symptom business Platelet factor 4

description

CXC chemokines display pleiotropic effects participating not only in inflammation, but regulating angiogenesis and metastatic spread in cancer. Platelet factor 4 (PF4) is a 70-amino acid protein belonging to the CXC chemokine family. PF4 is also known as CXCL4. This chemokine is released from alpha-granules of activated platelets and binds with high affinity to heparin-like molecules promoting coagulation. Megakaryocytes respond to the presence of tumors by increasing their number in the bone marrow accompanied by increase in the number of platelets in circulation, causing changes in chemokine balance.

year	journal	country	edition	language
2012-11-01	Journal of Translational Medicine

https://doi.org/10.1186/1479-5876-10-s3-p9

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