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RESEARCH PRODUCT
July 2003: 62-year-old female with progressive muscular weakness
Ronald L. HamiltonAntje BornemannJ¨rgen BohlHans-michael SchneiderHans H. GoebelPeter F. SchmidtRoamain K. Gherardisubject
Viral Hepatitis Vaccinesmedicine.medical_specialtyAluminum HydroxideMass SpectrometryCases of the Month: July to September 2003Pathology and Forensic MedicineDiagnosis DifferentialBiopsymedicineHumansMuscle SkeletalMyopathyInclusion BodiesHepatitisMuscle WeaknessPelvic girdlemedicine.diagnostic_testbusiness.industryMacrophagesGeneral NeuroscienceMacrophagic myofasciitisMiddle Agedmedicine.diseaseMuscular Dystrophy FacioscapulohumeralSurgeryVaccinationMicroscopy ElectronFacial musclesmedicine.anatomical_structureFemaleNeurology (clinical)medicine.symptombusinessProgressive muscular weaknessdescription
The July 2003 Case of the Month (COM). A 62-year-old female patient experienced progressive muscular weakness over the last ten years, involving shoulder and pelvic girdle muscles, paraspinal and facial muscles. A biopsy was taken from the left deltoid muscle where hepatitis vaccination had taken place 4 weeks previously. The specimen revealed macrophagic myofasciitis due to the injection of aluminium-bound vaccines. The finding can be reproduced experimentally by injecting vaccines in rats. The pathomechanism is supposed to involve immune stimulation due to long term persistence of the adjuvant. Macrophagic myofasciitis has been suggested to occasionally cause myopathy but is supposed to be unrelated to the underlying myopathy in our patient.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-03-05 | Brain Pathology |