showing 36 of ~574560 from 574555 documents
Satisfaction with and reliability of in-hospital video-EEG monitoring systems in epilepsy diagnosis – A German multicenter experience
2021
OBJECTIVE: To analyze satisfaction with and reliability of video-electroencephalography-monitoring systems (VEMS) in epilepsy diagnostics.; METHODS: A survey was conducted between December 2020 and January 2021 among German epilepsy centers using well-established customer satisfaction (CS) and quality assurance metrics.; RESULTS: Among 16 participating centers, CS with VEMS was low, with only 13% of customers actively recommending their system. Only 50% of users were satisfied with the overall performance of their VEMS, and a low 18% were satisfied with the manufacturer's customer service. User interface, software stability, lack of regular updates, and missing customer-oriented improvement…
Parametric estimation of non-crossing quantile functions
2021
Quantile regression (QR) has gained popularity during the last decades, and is now considered a standard method by applied statisticians and practitioners in various fields. In this work, we applied QR to investigate climate change by analysing historical temperatures in the Arctic Circle. This approach proved very flexible and allowed to investigate the tails of the distribution, that correspond to extreme events. The presence of quantile crossing, however, prevented using the fitted model for prediction and extrapolation. In search of a possible solution, we first considered a different version of QR, in which the QR coefficients were described by parametric functions. This alleviated th…
Relief and calcium from gypsum as key factors for net inorganic carbon accumulation in soils of a semiarid Mediterranean environment
2021
Abstract In semiarid environments, the total inorganic carbon (TIC) in soil may contribute to the total carbon (C) pool more than the total organic C pool (TOC), thus playing a key role in storing atmospheric CO2. However, due to the different origin pathways of soil carbonates, not all of the TIC pool can be accounted for CO2 sequestration. Indeed, the inorganic C can be accounted for a net sink of CO2 only when calcium (Ca2+) forming carbonates originate from non-carbonate minerals (atmogenic inorganic C, AIC). The aim of this study carried out in a gypsiferous area is to investigate the dissolution of Ca2+ that comes from gypsum (CaSO4·2H2O) in the formation of soil atmogenic carbonates …
COVID-19 Pandemic and Reduced Physical Activity: Is There an Impact on Healthy and Asthmatic Children?
2021
Physical activity (PA) has been seen to improve asthma symptoms, lung function, and quality of life, as well as to reduce airway inflammation and bronchial responsiveness. As a consequence of the COVID-19 pandemic, the minimal amount of PA recommended by the World Health Organization—i.e., about 60 min/day of moderate-to-high intensity—is difficult to achieve for many children, particularly those living in urban areas. Short-term changes in PA because of the COVID-19 pandemic may become habitual, increasing the risk of adverse asthma outcomes in children. Indeed, prolonged home confinement during the COVID-19 pandemic reduces PA levels and increases sedentary behaviors, possibly impairing i…
Adipose stem cell spheroids-laden hydrogels for minimally invasive bone and cartilage regeneration interventions
2021
Present and Perspectives of Photoactive Porous Composites Based on Semiconductor Nanocrystals and Metal-Organic Frameworks
2021
This review focuses on the recent developments in synthesis, properties, and applications of a relatively new family of photoactive porous composites, integrated by metal halide perovskite (MHP) nanocrystals and metal-organic frameworks (MOFs). The synergy between the two systems has led to materials (MHP@MOF composites) with new functionalities along with improved properties and phase stability, thus broadening their applications in multiple areas of research such as sensing, light-harvesting solar cells, light-emitting device technology, encryption, and photocatalysis. The state of the art, recent progress, and most promising routes for future research on these photoactive porous composit…
Un dépotoir domestique du Moyen Âge central (XIe-XIIe s.) dans l’établissement de Saint-Martin le Bas à Gruissan (Aude). Éclairage pluridisciplinaire…
2021
International audience; La fouille d’un dépotoir du Moyen Âge central dans l’établissement littoral de Saint-Martin le Bas à Gruissan, situé au coeur de la lagune narbonnaise, a livré une abondante documentation matérielle et bioarchéologique. L’étude exhaustive des restes collectés par une équipe pluridisciplinaire offre un éclairage inédit sur de nombreux aspects de la vie des occupants du site au cours des XIe-XIIe s. Elle démontre le caractère domestique des activités consommatrices qui ont généré les déchets rejetés dans le dépotoir, découlant assurément de la présence d’un habitat à proximité. Ces déchets reflè- tent une économie s’appuyant sur l’exploitation de la quasi-totalité de l…
Speeding up liquid-phase heavy element chemistry: Development of a vacuum to liquid transfer chamber (VLTC)
2021
Abstract We present a new system, which is suitable for performing fast liquid phase chemistry experiments and gives access to shorter-lived isotopes of super heavy elements (SHE) than accessible with current techniques. With this novel vacuum to liquid transfer chamber (VLTC), which is mounted behind a physical preseparator, the desired isotopes are transported from the low-pressure side of the recoil separator directly into the liquid phase of a chemical experiment. Simulations on the kinematics of evaporation residues were performed using SRIM, validating the general plausibility of the VLTC concept. Subsequently, the feasibility was demonstrated with 250 , 252 Cf fission fragments, whic…
Thermal Stability of a DC/DC Converter with Inductor in Partial Saturation
2021
Inductors operated in quasi saturation in dc–dc converters allow reduction of the core size and realization costs; on the other hand, they imply an increase of dissipated power that can jeopardize the thermal stability of the converter. In this article, this issue is studied by a mathematical model able to represent both the inductor nonlinearity and its temperature dependence. The main losses, such as ohmic, skin effect and magnetic, are taken into account in the model. The inductor is characterized by a polynomial curve whose parameters are a function of the temperature. Finally, the whole converter is modeled and simulation results, obtained on a boost converter, are compared with experi…
Relationship between volume of submandibular salivary stones in vivo determined with cone-beam computer tomography and in vitro with micro-computer t…
2021
Background Successful removal of salivary stones depends on exact pretreatment information of the location, the size and shape of the stones. This study aimed to compare the volume of submandibular sialoliths determined by preoperative Cone-Beam Computer Tomography (CBCT) scans with the volume of the removed stones on micro-Computer Tomography (micro-CT) scans. Material and Methods In this study, using twenty-one submandibular sialoliths, the pretreatment volumes in-vivo measured on CBCT were compared to the volumes of removed stones determined by micro-CT scans. The volume measured on micro-CT scans served as the gold standard. Pre-operative CBCT’s and in-vitro micro-CT’s were converted in…
1535P Exploring the dynamic crosstalk between immune system and genetics in a cohort of 116 completely resected gastrointestinal stromal tumors (GIST…
2021
R-Score: A New Parameter to Assess the Quality of Variants’ Calls Assessed by NGS Using Liquid Biopsies
2021
Next-generation sequencing (NGS) has enabled a deeper knowledge of the molecular landscape in non-small cell lung cancer (NSCLC), identifying a growing number of targetable molecular alterations in key genes. However, NGS profiling of liquid biopsies risk for false positive and false negative calls and parameters assessing the quality of NGS calls remains lacking. In this study, we have evaluated the positive percent agreement (PPA) between NGS and digital PCR calls when assessing EGFR mutation status using 85 plasma samples from 82 EGFR-positive NSCLC patients. According to our data, variant allele fraction (VAF) was significantly lower in discordant calls and the median of the absolute va…
Furió, A. (Ed.) (2020). En torno a la economía mediterránea medieval. Estudios dedicados a Paulino Iradiel. València: Publicacions de la Universitat …
2021
Reseña: Furió, A. (Ed.) (2020). En torno a la economía mediterránea medieval. Estudios dedicados a Paulino Iradiel. València: Publicacions de la Universitat de València, 2020. 402 pp. ISBN: 978-84-9134-661-6.
First detection of SARS-CoV-2 A.23.1 sub-lineage in migrants arriving to Italy via the Mediterranean Sea and public health implications
2021
In situ carbon and oxygen isotopes measurements in carbonates by fiber coupled laser diode-induced calcination: A step towards field isotopic charact…
2021
International audience; Natural stable isotopes ratios (δ13Ccarb and δ18Ocarb) of carbonates archived in the geological record are routinely used to reconstruct local and global paleo temperatures and the secular evolution of the biogeochemical carbon cycle. The state-of-the-art technique, employed since the mid 20th century, to measure these isotopic ratios starts with field sampling followed by several steps of physical and chemical laboratory preparation including: (i) microdrilling and/or sawing and crushing, (ii) CO2 release by wet acid digestion, (iii) gas equilibration, purification and transfer, before (iv) gas phase IRMS measurements. While these steps are time and resource consumi…
Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli
2021
Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can help sustain and control the delivery of antibacterial compounds while reducing the chances of antibacterial resistance or accumulation in unwanted tissues. In this study, novel chitosan gel beads were synthesized by a double ionic co-crosslinking mechanism. Tripolyphosphate and alginate, a polysaccharide obtained from marine brown algae, were employed as ionic cross-linkers to prepare the chitos…
Modelling regional-scale attenuation across Italy and the Tyrrhenian Sea
2021
Abstract Modelling regional-scale attenuation of seismic waves at ~1 Hz is challenging, especially when these waves propagate across both continental and oceanic crust. Recent developments in seismic imaging and modelling have provided us with the computational tools necessary to reconstruct these mixed settings using deterministic (coherent) and stochastic (coda) information. Here, we present new tomographic maps of coda-attenuation for both the Italian peninsula and the Tyrrhenian Sea. Kernel-based coda attenuation imaging in the diffusive approximation is tested in the oceanic environment, highlighting a non-diffusive behaviour across the Southern Tyrrhenian Sea. Joint deterministic and …
Localization of Viral Epitope-Specific CD8 T Cells during Cytomegalovirus Latency in the Lungs and Recruitment to Lung Parenchyma by Airway Challenge…
2021
Interstitial pneumonia is a life-threatening clinical manifestation of cytomegalovirus infection in recipients of hematopoietic cell transplantation (HCT). The mouse model of experimental HCT and infection with murine cytomegalovirus revealed that reconstitution of virus-specific CD8+ T cells is critical for resolving productive lung infection. CD8+ T-cell infiltrates persisted in the lungs after the establishment of latent infection. A subset defined by the phenotype KLRG1+CD62L− expanded over time, a phenomenon known as memory inflation (MI). Here we studied the localization of these inflationary T effector-memory cells (iTEM) by comparing their frequencies in the intravascular and transm…
East vs. West: Differences in the prevalence of child maltreatment in Germany before the reunification
2021
The last century of the Chora Monastery: a new look at the tomb monuments
2021
Abstract The present article re-examines the tomb monuments in the parekklesion and the outer narthex of the main church of the Chora monastery, which are generally thought to date from the early Palaiologan period. Based on the analysis of the iconography and style of the frescoes adorning the tombs, it is suggested that some of the burials should be re-dated at least a few decades later. The frescoes in the lunette of the Tomb of Michael Tornikes (Tomb D) appear to have been executed shortly after 1350 and the decoration of Tombs C and E must date from around the same time. The portraits in Tombs F and G date from the 15th century. The epigraphic evidence and the images illustrate the con…
Syntrophy of Crypthecodinium cohnii and immobilized Zymomonas mobilis for docosahexaenoic acid production from sucrose-containing substrates
2021
Marine heterotrophic dinoflagellate Crypthecodinium cohnii is an aerobic oleaginous microorganism that accumulates intracellular lipid with high content of 4,7,10,13,16,19-docosahexaenoic acid (DHA), a polyunsaturated ω-3 (22:6) fatty acid with multiple health benefits. C. cohnii can grow on glucose and ethanol, but not on sucrose or fructose. For conversion of sucrose-containing renewables to C. cohnii DHA, we investigated a syntrophic process, involving immobilized cells of ethanologenic bacterium Zymomonas mobilis for fermenting sucrose to ethanol. The non-respiring, NADH dehydrogenase-deficient Z. mobilis strain Zm6-ndh, with high ethanol yield both under anaerobic and aerobic condition…
Westwärts und nicht vergessen. Innerdeutsche Migration und psychosoziale Folgen 1990 - 2020
2021
Medulloblastoma in Adulthood
2021
Abstract Defined as a tumour with increased malignancy potential in childhood, medulloblastoma was first reported in the literature by Percival Bailey and Harvey Cushing in 1925. Scientific studies over the years have shown that this type of tumour represents about 20% of all intracranial tumours encountered in childhood, their percentage decreasing with advancing age. The genetic factor plays an important part in the appearance of medulloblastoma; there are certain diseases, in the patient’s history, that can be associated with this type of tumour. Here, we can specify Turcot syndrome (an autosomal recessive disease, rarely encountered) or basal cell carcinoma syndrome. This article presen…
The Impact of the COVID-19 Pandemic on ICU Healthcare Professionals: A Mixed Methods Study
2021
The large numbers of patients admitted to intensive care units due to COVID-19 has had a major impact on healthcare professionals. The incidence of mental health disorders among these professionals has increased considerably and their professional quality of life has suffered during the pandemic. This study aims to explore the impact of the provision of COVID-19 patient care on ICU healthcare professionals. A mixed methods study with an exploratory concurrent design was conducted between June and November 2020 in the Balearic Islands, Spain. Data were collected using a self-report online survey (n = 122) based on three validated questionnaires, and individual semi-structured in-depth online…
La table, un espace de socialité. Regards croisés sur les agapes et autres banquets
2021
International audience
ça brasse dans les arts de la table. Des verres à bière
2021
International audience
Evidence of shadowing in inelastic nucleon-nucleon cross section
2021
The Glauber modeling plays a key role in centrality-dependent measurements of heavy-ion collisions. A central input parameter in Glauber models is the inelastic nucleon-nucleon cross section $\sigma_{\text{nn}}^{\text{inel}}$ which is nearly always taken from proton-proton measurements. At the LHC energies $\sigma_{\text{nn}}^{\text{inel}}$ depends on the QCD dynamics at small $x$ and low interaction scales where the shadowing/saturation phenomena are expected to become relatively more important for larger nuclei than for the proton. Thus, $\sigma_{\text{nn}}^{\text{inel}}$ e.g. in Pb+Pb collisions may well be lower than what is seen in proton-proton collisions. In this talk, we demonstrate…
Intraoperative brain mapping during awake surgery in symptomatic supratentorial cavernomas.
2021
Abstract Background Complete resection of symptomatic supratentorial cavernoma (SCA) and removal of the surrounding gliotic area is recommended to minimize the risk of persistent seizures or (re)bleeding. Surgery of SCA located in an eloquent area, can carry out severe postoperative neurological morbidity. We report a study aimed to assess feasibility, extent of resection and outcome after surgical removal of CA by cortico-subcortical intraoperative brain stimulation (ioBS) in the awake patient. Methods Six patients diagnosed of symptomatic SCA located on an eloquent area and operated on while awake under local anaesthesia ioBS, were included. Preoperative planning included neuropsychologic…
391MO Impact of diabetes and metformin use on recurrence and outcome in early colon cancer (CC) patients: A pooled analysis of 3 adjuvant trials
2021
Harmful Interference of Detoxifying Diets and Nutraceuticals with Adherence to Abemaciclib in Advanced Estrogen Receptor-Positive, Human Epidermal Gr…
2021
Many cancer patients use integrative therapies with a combination of natural products and diets. In the Western world, integrative medicine is often not shared with oncologists even during antineoplastic treatments. This behavior stems from the unmet needs of cancer patients who may feel oncologists’ underestimation of their symptoms and spiritual aspects. This case report demonstrates the potential harm of inadequate diet and nutraceutical intake in a 68-year-old woman with metastatic estrogen receptor-positive, human epidermal growth factor receptor-2-negative breast cancer. Her care team recommended hormone therapy with abemaciclib plus fulvestrant. Her diarrhea started after 10 days of …
Integral Reduction with Kira 2.0 and Finite Field Methods
2021
We present the new version 2.0 of the Feynman integral reduction program Kira and describe the new features. The primary new feature is the reconstruction of the final coefficients in integration-by-parts reductions by means of finite field methods with the help of FireFly. This procedure can be parallelized on computer clusters with MPI. Furthermore, the support for user-provided systems of equations has been significantly improved. This mode provides the flexibility to integrate Kira into projects that employ specialized reduction formulas, direct reduction of amplitudes, or to problems involving linear system of equations not limited to relations among standard Feynman integrals. We show…
The role of lithium, perchlorate and water during electrochemical processes in poly(3,4-ethylenedioxythiophene) films in LiClO4 aqueous solutions
2021
Abstract Thin films of poly(3,4-ethylendioxythiophene) (PEDOT) were electrochemically deposited on gold electrodes in aqueous media. The role of perchlorate, lithium, and water during the charge/discharge of PEDOT films was investigated by cyclic voltammetry together with EQCM, vis − NIR spectroscopy, and acoustic impedance, also by means of ac-electrogravimetry in a 0.1 M LiCl O 4 aqueous solutions. In this way, it has been possible to correlate the electrical, mass, color and electromechanical properties changes during the electrochemical reactions of this polymer. Both, hydrated lithium cations and perchlorate anions can act as counterions during the electrochemical reactions, however, a…
La loi "Climat et résilience" et les baux d'habitation
2021
International audience
Implementation of computed tomography angiography (CTA) and computed tomography perfusion (CTP) in Polish guidelines for determination of cerebral ci…
2021
Background: Brain death/death by neurologic criteria (BD/DNC) guidelines are routinely analyzed, compared and updated in the majority of countries and are later implemented as national criteria. At the same time, extensive works have been conducted in order to unify clinical procedures and to validate and implement new technologies into a panel of ancillary tests. Recently evaluated computed tomography angiography and computed tomography perfusion (CTA/CTP) seem to be superior to traditionally used digital subtraction angiography (DSA), transcranial Doppler (TCD) and cerebral perfusion scintigraphy for diagnosis of cerebral circulatory arrest (CCA). In this narrative review, we would like t…
Comparison of different hollow fibre haemodialysis module configurations by a CFD multiscale approach
2021
Objectives The study aims to predict 3-D flow and solute concentrations fields both for blood and dialysate and overall performance parameters (such as dialysate pressure drop and clearance) for different hollow-fibre haemodialysis modules. Methods A multiscale approach was used. At small (unit cell)-scale, dialysate flow and mass transfer around straight cylindrical fibres arranged in regular lattices were simulated. At module-scale, hydraulic permeabilities and mass transfer coefficients derived from small-scale simulations were used to define two different porous media representative of blood and dialysate, sharing the same volume and exchanging solute. Simulations involved different mod…