Search results for " 2"
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In-Depth Characterization of Bioactive Extracts from Posidonia oceanica Waste Biomass
2019
© 2019 by the authors.
Could a cooperation network between Finnish universities advance adoption and success of Green Office environmental management system?
2013
Finnish universities are increasingly adopting EMSs in order to improve their sustainability performance. Theoretical background includes studies on EMS implementation in universities and sustainability networks. Insufficient management commitment leading to lack of resources and time has been identified as a common hindering factor with regard to implementation of said systems. This study is an empirical research on the possibilities of an inter- university network in facilitating the implementation of the Green Office EMS. The study is providing answers to the following questions: whether a university Green Office cooperation network could assist the progress of the programme and in what …
Oppdragelsessyn i endring? : En komparativ studie av populære oppdragelsesbøker utgitt i Norge i perioden 1950-2000
2017
Masteroppgave pedagogikk PED511 - Universitetet i Agder 2017 The topic of this assignment is to study if the view of parenting has changed in Norway. There have been many discussions about parenting and what it entails. This study is limited to popular books that have been released in Norway between 1950 and 2000. The parenting books emphasise different aspects in the children’s upbringing and how that positively affects their development. The primary research question is to examine the views of parenting and its development from four books from the selected period: “Barneoppdragelse” by Lise Østlyngen (1950), “Barn og foreldre: barneoppdragelse i praksis” by Hambro & Moa (1966), “Elsker du…
Sueños y violencias, migrantes latinoamericanas en su paso por México
2019
Meme marketing: How marketers can drive better engagement using viral memes?
2022
Scholars and industry stakeholders have exhibited an interest in identifying the underlying dimensions of viral memes. However, the recipe for creating a viral meme remains obscure. This study makes a phenomenological contribution by examining viral memes, exploring the antecedents (i.e., content-related factors, customer-related factors, and media-related factors), consequences, and moderating factors using a mixed-method approach. The study presents a holistic framework for creating viral memes based on the perceptions of customers and industry stakeholders. Four quantitative studies (i.e., a lab experiment, an online quasi-experiment, an event study, and a brand recall study) validate th…
Replication of herpes simplex virus type 1 and 2 in the medulla of the adrenal gland after vaginal infection of mice.
1996
After vaginal infections of mice with neuroinvasive strains of herpes simplex virus type 1 and 2 (HSV-1, HSV-2) virus replicates in the epithelium of the vagina, in the paravaginal ganglia, in the spinal cord and finally in the brain and in the adrenal glands. However, viral antigens could be demonstrated only in the medulla of the adrenal glands but not in the cortex, as assessed by immunohistochemistry (IHC). HSV could not be isolated from liver, spleen, uterus, and ovaries. This contrasts to the intraperitoneal (i.p) route of infection with replication in different visceral organs including the adrenal gland's cortex.
Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry
2013
ABSTRACT Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and lipid rafts but required actin polymerization and tetraspanin CD151, and the viruses were routed to the same LAMP-1-positive compartment. Hence, the viruses shared similar cellular requirements for endocytic entry.
Impact of VP1-Specific Protein Sequence Motifs on Adeno-Associated Virus Type 2 Intracellular Trafficking and Nuclear Entry
2012
ABSTRACT Adeno-associated virus type 2 (AAV2) has gained much interest as a gene delivery vector. A hallmark of AAV2-mediated gene transfer is an intracellular conformational change of the virus capsid, leading to the exposure of infection-relevant protein domains. These protein domains, which are located on the N-terminal portion of the structural proteins VP1 and VP2, include a catalytic phospholipase A 2 domain and three clusters of basic amino acids. We have identified additional protein sequence motifs located on the VP1/2 N terminus that also proved to be obligatory for virus infectivity. These motifs include signals that are known to be involved in protein interaction, endosomal sort…
The Extracellular δ-Domain is Essential for the Formation of CD81 Tetraspanin Webs
2014
AbstractCD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular δ-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The δ-domain is also essential for the platforms to function during viral entry. We propose that, ins…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…