Search results for " 4"
showing 10 items of 3131 documents
Examining the generalizability of research findings from archival data
2022
This research project benefitted from Ministry of Education (Singapore) Tier 1 Grant R-313-000-131-115 (to A. Delios), National Science Foundation of China Grants 72002158 (to H.T.) and 71810107002 (to H.T.), grants from the Knut and Alice Wallenberg Foundation (to A. Dreber) and the Marianne and Marcus Wallenberg Foundation (through a Wallenberg Scholar grant; to A. Dreber), Austrian Science Fund (FWF) Grant SFB F63 (to A. Dreber), grants from the Jan Wallander and Tom Hedelius Foundation (Svenska Handelsbankens Forskningsstiftelser; to A. Dreber), and an Research & Development (R&D) research grant from Institut Européen d'Administration des Affaires (INSEAD) (to E.L.U.). Dmitrii Dubrov, o…
Industry 4.0 vs. Industry 5.0 : Co-existence, Transition, or a Hybrid
2023
Smart manufacturing is being shaped nowadays by two different paradigms: Industry 4.0 proclaims transition to digitalization and automation of processes while emerging Industry 5.0 emphasizes human centricity. This turn can be explained by unprecedented challenges being faced recently by societies, such as, global climate change, pandemics, hybrid and conventional warfare, refugee crises. Sustainable and resilient processes require humans to get back into the loop of organizational decision-making. In this paper, we argue that the most reasonable way to marry the two extremes of automation and value-based human-driven processes is to create an Industry 4.0 + Industry 5.0 hybrid, which inher…
Lake size and fish diversity determine resource use and trophic position of a top predator in high-latitude lakes
2015
Prey preference of top predators and energy flow across habitat boundaries are of fundamental importance for structure and function of aquatic and terrestrial ecosystems, as they may have strong effects on production, species diversity, and food-web stability. In lakes, littoral and pelagic food-web compartments are typically coupled and controlled by generalist fish top predators. However, the extent and determinants of such coupling remains a topical area of ecological research and is largely unknown in oligotrophic high-latitude lakes. We analyzed food-web structure and resource use by a generalist top predator, the Arctic charr Salvelinus alpinus (L.), in 17 oligotrophic subarctic lakes…
Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells
2011
Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by act…
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Jaunākā pirmsskolas vecuma bērnu labestīgas saskarsmes sekmēšana lomu rotaļās
2020
Bakalaura darba temats – “Jaunākā pirmsskolas vecuma bērnu labestīgas saskarsmes sekmēšana lomu rotaļās”. Bakalaura darba autore ir Liene Krumholce. Bakalaura darba mērķis: literatūras studiju rezultātā teorētiski izzināt dažādu autoru atziņas par bērnu vecumposmiem, labestīgas saskarsmes veidošanos, rotaļu nozīmi un praktiski vērtēt labestīgas saskarsmes veidošanās iespējas lomu rotaļās. Teorētiskajā daļā tiek analizēta literatūra par labestīgas saskarsmes veidošanos pieaugušo – bērnu, bērnu – bērnu saskarsmē. Izstrādāti jaunākā pirmsskolas vecumposma labestīgas saskarsmes raksturojoši kritēriji un noteikti labestīgu saskarsmi veicinoši nosacījumi. Analizēta lomu rotaļas organizācija bērnu…
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
Lo sciopero nell'ordinamento interno ed eurounitario
2019
Il saggio analizza l’evoluzione teorica del diritto di sciopero nell’ordinamento italiano e in quello europeo. Segnatamente, particolare attenzione viene dedicata all’elaborazione dottrinale sull’art. 40 Cost. e sulle teorie che inquadrano lo sciopero come diritto indivi - duale di libertà. Viene successivamente presa in esame la posizione dello sciopero nella Carta di Nizza, esaminando il valore del suo riconoscimento giuridico quale diritto sociale fondamentale.
Effect of Heat on the Adsorption Properties of Silica Gel
2012
Published version of an article in the journal: International Journal of Engineering and Technology. Also available from the publisher at: http://www.ijetch.org/papers/416-T886.pdf Open access. Adsorption properties of silica gel have been attributed to the surface hydroxyl groups of silica gel. Some hydroxyl groups are free standing and called free silanol groups. Some are hydrogen bonded to neighbouring silanol groups. Christy has shown that a high silanol number and a balanced concentration proportionality between these two different types of hydroxyl groups is necessary for effective adsorption of water molecules. Thermal treatment of silica gel samples alters the proportions of these g…
3 - 4 gadīgu bērnu saskarsmes prasmju sekmēšana kustību rotaļās
2019
Kvalifikācijas darba tēma – 3 – 4 gadīgu bērnu saskarsmes prasmju sekmēšana kustību rotaļās. Pētījuma mērķis – Pētīt 3 – 4 gadīgu bērnu saskarsmes prasmes kustību rotaļās. Darbs sastāv no 2 daļām – teorētiskās un praktiskās daļas. Teorētiskajā daļā tiek pētīts psihologu, filozofu un pedagogu atziņas par saskarsmi, sniegts saskarsmes vispārīgs raksturojums, 3 – 4 gadīgu bērnu vecumposma īpatnības un saskarsmes spēju veidošanās nosacījumi, kā arī analizētas kustību rotaļas kā līdzeklis saskarsmes prasmju sekmēšanai. Tiek apskatīti sekojošu autoru darbi – D.Elkoņins, D.Dzintare, I.Stangaine, Ļ.Vigotskis, A.Vorobjovs. Praktiskajā daļā tiek sniegts pētījumā pielietotu metožu raksturojums un atsp…