Search results for " ADR"

Reproductive Dysfunction in Classical and Nonclassical Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

2021

Patients with congenital adrenal hyperplasia (CAH) both with severe (classical CAH) and mild (nonclassical NCAH) forms exhibit a wide spectrum of reproductive dysfunction. In this review, only CAH cases with 21-hydroxylase deficiency (21-OHd) will be discussed, as they represent almost all of the patients in reproductive clinical settings.

Modifications contemporaines de la demande adressée au médecin

2010

HLADR5 and C4BQ0 high frequency and antinuclear antibodies positivity in patients with 21 hydroxylase deficiency from Campania region

1992

HLA haplotypes, complement C4 factor and factor B immonochemical concentrations and autoantibodies titer have been studied in six patients with mild congenital adrenal hyperplasia (MC-AH), in two patients with classical congenital adrenal hyperplasia (CCAH) and in their parents. A high frequency of DR5 and C4BQO alleles have been found in MCAH patients. Moreover, C4BQO allele is carried out in three out of four cases associated with DR5. In the two CCAH patients we found a B51 and a B14 allele, the last one usually described in the non classical form of the disease in population of different ethnic origin. Signs of autoimmunity in some patients and parents have been found. C4 null alleles w…

A mutation in the second intracellular loop of the pituitary adenylate cyclase activating polypeptide type I receptor confers constitutive receptor a…

2000

AbstractThe pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor belongs to the glucagon/secretin/vasoactive intestinal polypeptide (VIP) receptor family. We mutated and deleted an amino acid residue (E261) which is located within the second intracellular loop of the rat PACAP type I receptor and which is highly conserved among the receptor family. The wild-type receptor and the mutant receptors were efficiently expressed at the surface of COS-7 cells at nearly the same level and revealed the same high affinity for the agonist PACAP-27. The cAMP contents of COS cells transfected with the E261A, E261Q, and the deletion mutant receptor were 4.6-, 5.7-, and 6.7-fold highe…

Zeitlicher Ablauf der ACTH-induzierten Stimulierung der Corticosteroidbiosynthese

1969

The time course of ACTH action was studied during incubation of quartered rat adrenals by estimation of corticosterone production and secretion rates. The results suggest a two step action of ACTH during the acute stimulation of corticosteroid biosynthesis: A modest initial stimulation was observed within the first 30 min of exposure to ACTH which was overlapped by a marked secondary stimulation between 30 and 60 min.

Kombination und Rekombination in der Renaissance

2020

Ein hervorstechendes Merkmal der Musik des 15. und 16. Jahrhunderts ist die Verwendung von praexistenter Musik als Grundlage oder Ausgangspunkt einer neuen Komposition. Solche Werke lassen sich anhand zweier grundsatzlich unterschiedlicher Herangehensweisen unterscheiden, die jeweils eigene kompositionstechnische Probleme nach sich ziehen: Einerseits finden sich Kompositionen, die auf additiven Prozessen und kontrapunktisch anspruchsvollen Strukturen wie Kanons basieren, andererseits solche, in denen eine meist mehrstimmige Vorlage fragmentiert und ihre Bestandteile zu einer neuen Komposition rekombiniert werden. Im vorliegenden Artikel wird diese Unterscheidung ausgehend von Detailanalysen…

Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society.

2012

Background Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age. Methods We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of hirsutism. Results The prevalence of hirsutism is ~10% in most populations, with the important exception of Far-East Asian women who present hirsutism less frequently. Although usually caused by relatively benign functional conditions, with the polycystic ovary syndrome leading the list of the most frequent etiologies, hirsutism may be th…

Emediate training programme

2013

Si tratta di moduli di un programma di E-learning finanziato dalla Commissione Europea sulla linea "Civil Justice 2012"

Dialogo e modelli di mediazione

2016

L’idea di questo volume nasce nel 2014 dalla collaborazione tra i vari autori che Vi hanno contribuito, i quali hanno partecipato direttamente o indirettamente alle attività di ricerca, didattica e diffusione di un progetto comunitario in tema di mediazione, finanziato dalla Commissione Europea sulla linea Civil Justice 2012. Il progetto è stato coordinato dal Dipartimento di Studi Europei e della Integrazione Internazionale (DEMS) dell’Università di Palermo, in collaborazione con il Centro di Ricerche Economiche e Sociali per il Mediterraneo (CRESM), il Centro Mediterraneo di Studi Interculturali (CEMSI), l’Università del Pireo (Grecia), l’Università di Cipro, l’Università di Tilburg (Olan…

Adrenoceptor-mediated effects on calcium channel currents are antagonized by 5?-(N-ethyl)-carboxamido-adenosine in guinea-pig atrial cells

1992

In guinea-pig atrial myocytes, the effects of the adenosine analogue 5′-(N-ethyl)-carboxamido-adenosine (NECA) in the presence of isoprenaline (ISO) on Ca2+ channel activity were analyzed. Single Ca2+ channel currents were recorded from cell-attached patches by application of several hundred 100 ms depolarizing steps. Under control conditions, burstlike activity of channel openings during some depolarizing steps were followed by variably long periods of quiescence (blank sweeps). During superfusion with ISO (100 nmol/l), ensemble-averaged (mean) current was increased by about 150%. The underlying mechanism was found to be a significant increase in the channel availability, defined as the ra…