Search results for " Aging"
showing 10 items of 584 documents
Shear bond strength of a flash-free orthodontic adhesive system after thermal aging procedure.
2019
Background The aim of this study was to compare the shear bond strength (SBS) of a flash-free and precoated orthodontic adhesive with a compomer orthodontic adhesive before and after thermocycling. The adhesive remnant index (ARI) was also determined for both adhesives. Material and Methods The adhesive remnant index (ARI) was also determined for both adhesives. Material and Methods: A total of 120 human premolars were randomly divided into two groups (n=60) according to the orthodontic adhesive used: APC Flash-Free Adhesive Coated Appliance System (APC FF) or Transbond PLUS Color Change Adhesive (TP), as control. A SBS test was performed and ARI value for each specimen was also assessed. R…
Enhancing Joined-Up Government and Outcome-Based Performance Management through System Dynamics Modelling to Deal with Wicked Problems: the Case of S…
2015
The paper by Auping et al. (2015) focuses on the topic of societal 'ageing', that is, 'a population process, caused by declining fertility and mortality rates, which manifests itself in the growing number of older persons in society' (Huber, 2005). A broader definition frames societal ageing as a 'demographic, structural, cultural and economic transformation resultant from the increase in the number and proportion of " older " people within society' (Victor, 2005, p. 5). 'Double societal ageing' today characterizes most developed countries, which experience both an increase in the percentage of older people and in their life expectancy. In terms of public policy and finance, the relevance o…
Exercise as a calorie restriction mimetic. Implications for the treatment of age associated frailty
2018
The free radical theory of aging has provided a theoretical framework for an enormous amount of work leading to advances in our understanding of aging. A critical blow to the free radical theory of aging came from epidemiological studies showing that antioxidant supplementation did not lower the incidence of age-associated diseases. However, work from many laboratories supports the theory, for instance showing that overexpression of antioxidant enzymes results in increases not only in life-span but also in health-span. Improving healthy aging means delaying disability. Disability is often preceded by a state characterized by reduced capacity to respond to stressors, caused by a decline in f…
Tracer aroma compound transfer from a solid and complex-flavored food matrix packed in treated papers or plastic packaging film.
2007
The objective of this work was to study the transfer of four aroma compounds (ethyl butyrate, ethyl hexanoate, cis-3-hexenol, and benzaldehyde) from a solid and complex-flavored food matrix (sponge cake) toward and through packaging films placed in indirect contact during storage in accelerated aging conditions (38 °C and 86% relative humidity gradient). The efficiency of treated papers relative to that of standard paper and plastic as barrier was tested. Before storage, aroma compound volatility in the sponge cake was measured, and similar values were found between aroma compounds, due to the fat content of the sponge cake. Whatever the aroma compound, permeability values during storage we…
Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
2021
The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential. Among the different niche components, vasculature has gained increasing interest over the years due to its undeniable role in NSC regulation and its therapeutic potential for neurogenesis enhancement. NSCs are uniquely positioned to receive both locally secreted factors and adhesion-…
Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review
2019
Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular levels. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflammaging, is a common biological factor responsible for the decline and beginning of the disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of …
G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson's Disease?
2019
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the …
The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study.
2020
Background In esthetic medicine, different techniques have been used against the aging of the human skin especially in the facial area. Hyaluronic acid is used for improving the quantity of water and extracellular matrix molecule. The aim of this study is a clinical and histological evaluation of the effect of low-molecular-weight hyaluronic acid fragments mixed with amino acid (HAAM) on the rejuvenation the face skin treated with intradermal microinjections. Methods Twenty women with mean age 45 range from 35 to 64 were studied, thereof 8 in menopause and 12 of childbearing age. The patients were treated with the HAAM products by mesotherapy technique; before and after 3 months of the ther…
Correlation between CD117+ myeloma plasma cells and hematopoietic progenitor cells in different categories of patients
2015
Background Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of the cPC immunophenotype and alterations involving other cells in BM, but rarely these data are interpreted as connected. One exception to this habit are previous studies about relationship between CD117 cPC positivity and hematopoietic progenitor cell (HPC) distribution in newly diagnosed patients. Thus we were interested in verifying the distribution of BM CD34+ HPCs in heal…
Influence of pillar 3 of pension system on retirement pensions level in Poland : will voluntary part of system enable decent life in old age?
2021
PURPOSE: The aim of this paper is the comparative analysis of the general saving ways included in pillar 3 of the pension system and showing their potential effectiveness from the perspective of the pension system participant. Will the resources allocated by the instruments of the voluntary pension system part significantly improve the level of the future pension? Will they allow a more decent life for an average Polish citizen in the period of the old age?