Search results for " Assembly"

Protection of the right to freedom of assembly and association under ECHR: compliance difficulties in Azerbaijan

2018

The protection of the right to freedom of peaceful assembly and association under the ECHR and compliance difficulties in Azerbaijan, regarding these rights are discussed in this master thesis. The protection of the right to freedom of peaceful assembly and association is one of the critical elements for the development of democracy, and these rights are protected by international documents such as the European Convention for the Protection of Human Rights and Fundamental Freedoms (hereinafter referred as the European Convention on Human Rights or the ECHR). Furthermore, the protection of these rights at national level must be compatible with the standards of the Council of Europe. The impo…

Programmable assembly of peptide amphiphile via noncovalent-to-covalent bond conversion

2017

Controlling the number of monomers in a supramolecular polymer has been a great challenge in programmable self-assembly of organic molecules. One approach has been to make use of frustrated growth of the supramolecular assembly by tuning the balance of attractive and repulsive intermolecular forces. We report here on the use of covalent bond formation among monomers, compensating for intermolecular electrostatic repulsion, as a mechanism to control the length of a supramolecular nanofiber formed by self-assembly of peptide amphiphiles. Circular dichroism spectroscopy in combination with dynamic light scattering, size-exclusion chromatography, and transmittance electron microscope analyses r…

Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.

1997

Abstract Histones are thought to play a key role in regulating gene expression at the level of DNA packaging. Recent evidence suggests that transcriptional activation requires competition of transcription factors with histones for binding to regulatory regions and that there may be several mechanisms by which this is achieved. We have characterized a human nucleosome assembly protein, NAP-2, previously identified by positional cloning at 11p15.5, a region implicated in several disease processes including Wilms tumor (WT) etiology. The deduced amino acid sequence of NAP-2 indicates that it encodes a protein with a potential nuclear localization motif and two clusters of highly acidic residue…

Digital processing of environmental noise samples

2014

YK:n legitimiteetti yleiskokouksen kautta tarkasteltuna

2022

Legitimiteetti tai legitiimisyys on yksi Yhdistyneiden kansakuntien (YK) toiminnan kannalta keskeisistä käsitteistä, joka linkittyy myös monenkeskiseen yhteistyöhön ja siihen sitoutumiseen. Tässä katsausartikkelissa tarkastellaan YK:n legitimiteettiä yleiskokouksen näkökulmasta ja kysytään, miten yleiskokouksen uudistamista koskeva keskustelu vaikuttaa puolestaan koko YK:n legitimiteettiin. Erityisenä kiinnostuksen kohteena on kirjallisuudessa vähälle huomiolle jäänyt YK:n yleiskokous kansainvälisen politiikan toimijana ja yleiskokouksen mandaatti toimia eri kansainvälisen politiikan alaan kuuluvissa kysymyksissä. Artikkeli osoittaa, miten yleiskokouksella on tärkeä tehtävä koko YK:n kannal…

Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts

2021

The centromere is a fundamental chromosome structure in which the macro-molecular kinetochore assembles and is bound by spindle microtubules, allowing the segregation of sister chromatids during mitosis. Any alterations in kinetochore assembly or functioning or kinetochore–microtubule attachments jeopardize chromosome stability, leading to aneuploidy, a common feature of cancer cells. The spindle assembly checkpoint (SAC) supervises this process, ensuring a faithful segregation of chromosomes. CENP-E is both a protein of the kinetochore and a crucial component of the SAC required for kinetochore–microtubule capture and stable attachment, as well as congression of chromosomes to the metaphas…

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

1996

International audience; Friedreich's ataxia (FRDA) is an autosomal recessive, degenerative disease that involves the central and peripheral nervous systems and the heart. A gene, X25, was identified in the critical region for the FRDA locus on chromosome 9q13. This gene encodes a 210-amino acid protein, frataxin, that has homologs in distant species such as Caenorhabditis elegans and yeast. A few FRDA patients were found to have point mutations in X25, but the majority were homozygous for an unstable GAA trinucleotide expansion in the first X25 intron.

Nano composite membrane-electrode assembly formation for fuel cell-modeling aspects

2007

Long term stability is an essential requirement for fuel cell applications in automobile and stationary energy systems. In these systems the agglomeration of the catalyst nanoparticles is a well-known phenomenon which cannot be easily overcome or compensated for by re-designing the system. A direct result of this occurrence is the irreversible decrease of the electrochemical performance. Irregularities in electric field distribution are one root cause for migration and subsequent agglomeration of the catalyst nanoparticle. In this work, the impact of the electrode mechanical deformation on electric field distribution was studied using a computer modeling approach. Model of a Proton Exchange…

Mosaic Qβ coats as a new presentation model

1998

The new protein carrier was developed on the basis of recombinant RNA phage Qbeta capsid. C-terminal UGA extension of the short form of Qbeta coat, so-called A1 extension, served as a target for presentation of foreign peptides on the outer surface of mosaic Qbeta particles. In conditions of enhanced UGA suppression, the proportion of A1-extended to short coats in mosaic particles dropped from 48% to 14%, with an increase of the length of A1 extension. A model insertion, short preS1 epitope 31-DPAFR-35 of hepatitis B surface antigen, demonstrated superficial location on the mosaic Qbeta particles and ensured specific antigenicity and immunogenicity.

Supramolecular assembly of pyrene-tetrathiafulvalene hybrids on graphene: Structure-property relationships and biosensing activity

2021

Two different molecular receptors (1 and 2) incorporating one and three pyrene units to promote the π–π interaction with the basal plane of graphene are reported. In order to modulate the electronic properties of graphene, the new receptors are endowed with an electron-donor tetrathiafulvalene moiety (exTTF). The resulting non-covalent hybrids have been characterized by different analytical, spectroscopic and microscopic techniques (TGA, Raman, UV-Vis absorption, TEM and XPS), and the supramolecular interaction of the molecular systems with graphene has been investigated by theoretical calculations. The electrochemical behavior of the pyrene-exTTF hybrids onto distinct graphene-based materi…