Search results for " Atopic"

showing 10 items of 46 documents

The MOAHLFA index of irritant sodium lauryl sulfate reactions: first results of a multicentre study on routine sodium lauryl sulfate patch testing

2004

In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25% and 0.5% aq. has been added to routine allergen patch tests to assess its properties as a convenient diagnostic indicator of individual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors of contact allergy to many allergens, e.g. summarized in the 'MOAHLFA index', the impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 particip…

AdultMalemedicine.medical_specialtyTime FactorsHand DermatosesDermatologyLeg Dermatosesmedicine.disease_causeLogistic regressionSeverity of Illness IndexDermatitis Atopic030207 dermatology & venereal diseases03 medical and health sciencesSex Factors0302 clinical medicineAllergenRisk FactorsmedicineHumansImmunology and AllergyRisk factorintegumentary systemChemistryConfoundingAge FactorsSodium Dodecyl SulfatePatch testConfounding Factors EpidemiologicPatch Testsmedicine.diseaseDermatology3. Good healthSurgeryDermatitis Occupational030220 oncology & carcinogenesisToxicityIrritantsDermatitis IrritantFemaleDisease SusceptibilityIrritationContact dermatitisFacial DermatosesContact Dermatitis
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Eustachian Tube Function Assessment after Radiofrequency Turbinate Reduction in Atopic and Non-Atopic Patients.

2021

(1) Background: Inferior turbinates&rsquo

Adultmedicine.medical_specialtyEustachian tube functionHealth Toxicology and Mutagenesismedicine.medical_treatmentlcsh:MedicineTurbinatesGastroenterologyArticleMuscle hypertrophyturbinate hypertrophy03 medical and health sciences0302 clinical medicineInternal medicineSurveys and QuestionnairesmedicineNon atopicHumansIn patient030223 otorhinolaryngologyEar DiseasesReduction (orthopedic surgery)Agedmedicine.diagnostic_testbusiness.industryEustachian TubeSignificant differencelcsh:RPublic Health Environmental and Occupational Healtheustachian tube dysfunction (ETD)TympanometryEustachian tube dysfunctionMiddle Agedchronic nasal obstructionAcoustic Impedance Tests030220 oncology & carcinogenesisETDQ-7businessInternational journal of environmental research and public health
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Depression and Serum Content of Serotonin in Adult Patients with Atopic Dermatitis

2020

Atopic dermatitis (AD) is a chronic skin disease with the etiology not yet conclusively established. Recent reports demonstrate the role of serotonin (5-hydroxytryptamine; 5-HT) in the pathogenesis of AD. The aim of this study was to investigate the relationship between the serum content of serotonin and depression in adult patients suffering from severe AD. There were 31 patients of the median age of 41 years enrolled into the study, who suffered from AD since childhood, and a control group that consisted of 14 healthy subjects. AD was diagnosed on the basis of Hanifin and Rajka criteria. The severity of skin lesions was assessed with the SCORing Atopic Dermatitis (SCORAD) index and that o…

Affective symptoms; Atopic dermatitis; Depression; Serotonin; Skin lesions
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Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

2020

Atopic dermatitis (AD) is a prevalent inflammatory skin disease. Loss-of-function mutations in filaggrin gene (FLG) represent the strongest genetic risk factors for AD, being strongly associated with early disease onset and persistence into adulthood.1 The epidermis of individuals with mutations in FLG is fundamentally different from normal skin being characterized by increased penetration of allergens.2 Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG (R501X, 2282del4) on the development of early-onset AD.3 This finding was replicated for the 2282del4 FLG mutation in a Dutch cohort study, and extended to further associate with…

AllergyAllergyImmunologyFilaggrin ProteinsDermatitis Atopic03 medical and health sciences0302 clinical medicineCAT EXPOSUREIntermediate Filament ProteinsmedicineImmunology and AllergyAnimalsHumansGenetic Predisposition to Disease030304 developmental biologyRISK0303 health sciencesScience & TechnologyCATSbusiness.industryInfant NewbornAtopic dermatitismedicine.disease030228 respiratory system1107 ImmunologyMutation (genetic algorithm)ImmunologyMutationCatsbusinessLife Sciences & BiomedicineFilaggrinAllergy
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Cat Allergy as a Source Intensification of Atopic Dermatitis in Adult Patients

2020

Atopic dermatitis (AD) is characterized by exacerbations and remissions of eczematous skin, underlain by impaired skin barrier and aberrant Th2-type and Th-22 cytokine production. A number of allergens, in particular contact with fur animals, may aggravate the disease. This study seeks to define the influence of having a regular contact with a pet cat at home on the severity of symptoms and signs of AD. We addressed the issue using the SCORing Atopic Dermatitis (SCORAD) and visual analog (VAS) scores to assess the intensity of pruritus and by measuring the blood content of specific IgE and IL-4, IL-13, and IL-22 cytokines. The study group consisted of 47 adult patients suffering from AD sin…

Allergy; Animal fur allergen; Atopic dermatitis; Inflammation; Interleukins; Pet cat; Skin pruritus.
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Opposing functions of thymic stromal lymphopoietin–responsive basophils and dendritic cells in a mouse model of atopic dermatitis

2015

CD4-Positive T-Lymphocytes0301 basic medicineThymic stromal lymphopoietinImmunologyInflammationAdaptive ImmunityImmunoglobulin EDermatitis AtopicMice03 medical and health sciences0302 clinical medicineThymic Stromal LymphopoietinAnimalsImmunology and AllergyMedicineInterleukin 4Inflammationbiologybusiness.industryDendritic CellsAtopic dermatitisImmunoglobulin EAcquired immune systemmedicine.diseaseBasophilsMice Inbred C57BLDisease Models Animal030104 developmental biologyImmunologybiology.proteinCytokinesInterleukin-4medicine.symptombusiness030215 immunologyJournal of Allergy and Clinical Immunology
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CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children.

2005

BACKGROUND In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and interleukin (IL)-13 seems to play a pivotal role in the inflammatory network. We tried to assess the correlation between the immunological marker CD4(+)IL-13(+) and the clinical phase of extrinsic AD in children. METHODS Twenty children with AD were studied. Assessed parameters were: clinical severity (SCORAD index), total serum immunoglobulin E (IgE), blood eosinophil count, and percentage of CD4(+)IFNgamma(+), CD4(+)IL-4(+), CD4(+)IL-13(+) T cells. Determinations were carried out in the acute phase and after clinical remission were achieved. Ten nonatopic-matched children served as controls. RESULTS At baselin…

CD4-Positive T-LymphocytesMaleAllergyImmunologyCD4 T cellsEosinophilSettore MED/10 - Malattie Dell'Apparato Respiratoriointerleukin-13Immunoglobulin ESeverity of Illness IndexDermatitis AtopicSettore MED/13 - EndocrinologiaAtopyLeukocyte CountImmunopathologymedicineHumansImmunology and AllergySCORADChildmedicine.diagnostic_testbiologyatopic dermatitisbusiness.industrySeverity of Illness Index; Interleukin-13; Dermatitis Atopic; Humans; Child; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Leukocyte Count; Child Preschool; Eosinophils; Immunoglobulin E; Case-Control Studies; Female; MaleInterleukinallergy; atopic dermatitis; CD4 T cells; interleukin-13; Th1/Th2 cellsAtopic dermatitisEosinophilImmunoglobulin Emedicine.diseaseallergyCD4 Lymphocyte CountEosinophilsmedicine.anatomical_structureCD4-Positive T-LymphocyteCase-Control StudiesChild PreschoolImmunologybiology.proteinFemaleTh1/Th2 cellsbusinessCase-Control StudieHuman
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Therapeutic application of T cell receptor mimic peptides or cDNA in the treatment of T cell-mediated skin diseases

2000

An 8-amino acid peptide encoding a sequence of the transmembrane region of the T cell receptor alpha chain (TCR-alpha) was shown to inhibit T cell function by preventing functional assembly of the T cell receptor (mimic peptide). To avoid systemic immunosuppression by peptide application in vivo, we used a topical application of the peptide. In the system of murine contact sensitivity, topical application of the peptide inhibited the elicitation of contact sensitivity following application of a contact allergen in sensitized animals. Alternatively, when naked DNA encoding the peptide sequence was injected into skin before application of a contact allergen to sensitized animals, local immuno…

DNA ComplementaryReceptors Antigen T-Cell alpha-betaT-LymphocytesT cellGenetic enhancementPeptidePharmacologyBiologySkin DiseasesDermatitis AtopicMiceAntigenVaccines DNAGeneticsmedicineAnimalsHumansReceptorMolecular BiologyPeptide sequenceImmunosuppression Therapychemistry.chemical_classificationMice Inbred BALB CT-cell receptorAllergensPeptide Fragmentsmedicine.anatomical_structurechemistryNaked DNADermatitis Allergic ContactImmunologyMolecular MedicineGene Therapy
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Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization

2014

A murine repeated protein-patch model has been established to study epicutaneous sensitization in atopic dermatitis. This model has shown a predominant Th2 and a weak Th1 response in both BALB/c and C57BL/6 mice. However, Th responses induced in the repeated model are not consistent with the generally accepted theory that BALB/c and C57BL/6 mice are Th2 and Th1 prone and are representatives of human atopy and non-atopy, respectively. In this study, a single protein-patch model was established, which showed in addition to the Th2 response, a remarkable Th1 response in C57BL/6 mice, but not in BALB/c mice. Moreover, using muLangerin-DTR mice, we demonstrated that dermal dendritic cells, but n…

Dermal Dendritic CellsTh2 responseDermatologyBiochemistryDermatitis AtopicAtopyMiceTh2 CellsAntigens CDCell MovementmedicineAnimalsHumansEpicutaneous sensitizationMolecular BiologyCells CulturedSkinMice Inbred BALB Cbusiness.industryDendritic CellsAtopic dermatitisAllergensTh1 Cellsmedicine.diseaseMice Inbred C57BLLangerhans CellsImmunologyCytokinesTh1 responsebusinessIntegrin alpha ChainsExperimental Dermatology
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Patients Withdrawing Dupilumab Monotherapy for COVID-19-Related Reasons Showed Similar Disease Course Compared With Patients Continuing Dupilumab The…

2022

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Dupilumab TherapyAntibodies Monoclonal Humanized; Disease Progression; Humans; Treatment Outcome; COVID-19; Dermatitis AtopicDermatitisAtopic dermatitis.DermatologyDupilumabAntibodies Monoclonal HumanizedAntibodiesAtopicDermatitis AtopicSettore MED/35MonoclonalImmunology and AllergyHumanshumanHumanizedAtopic dermatitistreatment outcome Antibodies Monoclonal HumanizedCOVID-19Treatment OutcomeCOVID-19 Dupilumab Therapydisease exacerbationDisease ProgressionSettore MED/35 - MALATTIE CUTANEE E VENEREEHumanmonoclonal antibody atopic dermatiti
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