Search results for " Atrial"
showing 10 items of 156 documents
Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Resear…
2021
Abstract Background Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results A total of 9363 were available for this analysis. We identified three …
Heat Shock Protein-60 and Risk for Cardiovascular Disease
2011
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecularchaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60,the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotectivebut a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examplesof specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicatea pathogenic role for HSP60 but also its …
The Role of Patient-Specific Morphological Features of the Left Atrial Appendage on the Thromboembolic Risk Under Atrial Fibrillation
2022
BackgroundA large majority of thrombi causing ischemic complications under atrial fibrillation (AF) originate in the left atrial appendage (LAA), an anatomical structure departing from the left atrium, characterized by a large morphological variability between individuals. This work analyses the hemodynamics simulated for different patient-specific models of LAA by means of computational fluid–structure interaction studies, modeling the effect of the changes in contractility and shape resulting from AF.MethodsThree operating conditions were analyzed: sinus rhythm, acute atrial fibrillation, and chronic atrial fibrillation. These were simulated on four patient-specific LAA morphologies, each…
A particular bigeminy during atrial tachycardia, part II
2014
Joint use of cardio-embolic and bleeding risk scores in elderly patients with atrial fibrillation.
2013
VALUTAZIONE DEI MARKERS INFIAMMATORI E DEGLI INDICI DI DISFUNZIONE ENDOTELIALE IN UNA POPOLAZIONE DI PAZIENTI CON FIBRILLAZIONE ATRIALE PERMANENTE CO…
2022
Negli ultimi anni un numero crescente di studi ha sostenuto il ruolo dell'infiammazione nell'inizio, nel mantenimento e nell'outcome della fibrillazione atriale (FA). Tuttavia, nonostante una grande quantità di informazioni, è ancora oggetto di discussione se la fibrillazione atriale o la cardiopatia strutturale sottostante (SHD) sia la causa del processo infiammatorio. Abbiamo quindi cercato di determinare se il processo infiammatorio riflette una malattia sottostante o l'aritmia "di per sé". Pertanto abbiamo valutato i livelli plasmatici del recettore alfa solubile dell'interleuchina 2 (sIL-2Rα), TNF-α e IL-18 in una coorte di 100 pazienti con FA permanente arruolati consecutivamente (43 …
RENAL SALT WASTING: UNA SINDROME DA INAPPROPRIATA SECREZIONE DI URODILATINA? UNO STUDIO PILOTA
2022
La Renal Salt Wasting Syndrome (RSW) è una sindrome clinica con caratteristiche di laboratorio che si sovrappongono completamente alla sindrome da secrezione inappropriata di ADH (SIADH). La differenza fondamentale tra le due sindromi risiede nel volume extracellulare (ECV), ridotto nella RSW e normale o leggermente aumentato nella SIADH. Le difficoltà nella diagnosi differenziale di questa sindrome e nella comprensione del preciso meccanismo patogenetico hanno contribuito a mettere in discussione l'esistenza stessa di RSW. Considerando le caratteristiche della RSW, è stato studiato il possibile ruolo dei peptidi natriuretici per spiegare la sua patogenesi come ANP e BNP, con risultati inso…
An Automatic System for the Analysis and Classification of Human Atrial Fibrillation Patterns from Intracardiac Electrograms
2008
This paper presents an automatic system for the analysis and classification of atrial fibrillation (AF) patterns from bipolar intracardiac signals. The system is made up of: 1) a feature- extraction module that defines and extracts a set of measures potentially useful for characterizing AF types on the basis of their degree of organization; 2) a feature-selection module (based on the Jeffries-Matusita distance and a branch and bound search algorithm) identifying the best subset of features for discriminating different AF types; and 3) a support vector machine technique-based classification module that automatically discriminates the AF types according to the Wells' criteria. The automatic s…
Speckle tracking analysis: a new tool for left atrial function analysis in systemic hypertension: an overview
2014
Speckle tracking echocardiography (STE) is an imaging technique applied to the analysis of left atrial function. STE provides a non-Doppler, angle-independent and objective quantification of left atrial myocardial deformation. Data regarding feasibility, accuracy and clinical applications of left atrial strain are rapidly gathering. This review describes the fundamental concepts of left atrial STE, illustrates its pathophysiological background and discusses its emerging role in systemic arterial hypertension.
2015
Background and purpose Silent atrial fibrillation (AF) and tachycardia (AT) are considered precursors of ischaemic stroke. Therefore, detection of paroxysmal atrial rhythm disorders is highly relevant, but is clinically challenging. We aimed to evaluate the diagnostic value of natriuretic peptide levels in the detection of paroxysmal AT/AF in a pilot study. Methods Natriuretic peptide levels were analysed in two independent patient cohorts (162 patients with arterial hypertension or other cardiovascular risk factors and 82 patients with retinal vessel disease). N-terminal-pro-brain natriuretic peptide (NT-proBNP) and BNP were measured before the start of a 7-day Holter monitoring period car…