Search results for " BIOMEDICAL"

Meso-scale topological cues influence extracellular matrix production in a large deformation, elastomeric scaffold model

2018

Physical cues are decisive factors in extracellular matrix (ECM) formation and elaboration. Their transduction across scale lengths is an inherently symbiotic phenomenon that while influencing ECM fate is also mediated by the ECM structure itself. This study investigates the possibility of enhancing ECM elaboration by topological cues that, while not modifying the substrate macro scale mechanics, can affect the meso-scale strain range acting on cells incorporated within the scaffold. Vascular smooth muscle cell micro-integrated, electrospun scaffolds were fabricated with comparable macroscopic biaxial mechanical response, but different meso-scale topology. Seeded scaffolds were conditioned …

3D polylactide-based scaffolds for studying human hepatocarcinoma processes in vitro

2012

We evaluated the combination of leaching techniques and melt blending of polymers and particles for the preparation of highly interconnected three-dimensional polymeric porous scaffolds for in vitro studies of human hepatocarcinoma processes. More specifically, sodium chloride and poly(ethylene glycol) (PEG) were used as water-soluble porogens to form porous and solvent-free poly(L,D-lactide) (PLA)-based scaffolds. Several characterization techniques, including porosimetry, image analysis and thermogravimetry, were combined to improve the reliability of measurements and mapping of the size, distribution and microarchitecture of pores. We also investigated the effect of processing, in PLA-ba…

Macroporous Scaffolds Based on Chitosan and Bioactive Molecules†

2007

Chitosan-based macroporous scaffolds for tissue engineering applications are developed by cryogelation in aqueous media. The cryogels obtained are modified using a new RGD-containing peptide developed in this laboratory. A RGD-containing peptide is chemically attached to the surface of the cryogels to improve cell adhesion to the 3D-structure chitosan-based scaffolds. The synthesis, physico-chemical, and biological evaluations of the system are described, and the optimization of the formulations is carried out by varying the reaction parameters. Fibroblasts and endothelial cells are used in cell cultures to determine cell behavior and the cytocompatibility of the macroporous cryogels. Cell …

TCT-350 Safety and Performance of the Resorbable Magnesium Scaffold, Magmaris in a Real World Setting - First 400 Subjects at 12-month Follow-up of t…

2018

The aim of this registry is to investigate the clinical performance and long-term safety of the Resorbable Magnesium Scaffold (Magmaris) (BIOTRONIK AG, Buelach, Switzerland) in a real-world setting. Up to 2,054 subjects in up to 120 clinical sites in Europe, Asia, and Asia-Pacific countries will

A multiscale approach to automatic and unsupervised retinal vessel segmentation using Self-Organizing Maps

2016

In this paper an automatic unsupervised method for retinal vessel segmentation is described. Self-Organizing Map, modified Fuzzy C-Means, STAPLE algorithms and majority voting strategy were adopted to identify a segmentation of the retinal vessels. The performance of the proposed method was evaluated on the DRIVE database.

TEMPERATURE-TRIGGERED MACROSCOPIC GELATION OF IRRADIATED XYLOGLUCANS FOR BIOMEDICAL APPLICATIONS

2014

U-MedSearch: A Meta Search Engine of Medical Content for Different Users and Learning Needs

2015

More and more people use Internet to look for medical information for understanding and learning but different users, such as experts (e.g., physicians) and consumers (e.g., patients), have different needs and bring different levels of reading ability and prior knowledge. Generic and specific search engines and specialized health sites either do not exploit the whole web or overload users with information of different nature. On the contrary, it is important for a user to immediately find the information on the topic being explored that has the 'right' amount of information and level of complexity. This paper presents a meta search engine of medical information on the web, U-MedSearch, that…

Finding the best web medical content for different learner categories

2015

In the age of Internet where any kind of information can be easily found online, it is becoming increasingly evident that more and more people use the World Wide Web to seek health and medical information for understanding and learning. Different users have diverse needs, even when searching for the same topic. This is certainly true in healthcare, where a patient, a physician or a health executive might look for information on the same topic but have different necessities and bring different levels of reading ability and prior knowledge together with a different vocabulary. Generic search engines (like Google, Bing or Yahoo) work on the whole web but make generic searches often overloading…

Wearable Multisensor Ring-Shaped Probe for Assessing Stress and Blood Oxygenation: Design and Preliminary Measurements

2023

The increasing interest in innovative solutions for health and physiological monitoring has recently fostered the development of smaller biomedical devices. These devices are capable of recording an increasingly large number of biosignals simultaneously, while maximizing the user’s comfort. In this study, we have designed and realized a novel wearable multisensor ring-shaped probe that enables synchronous, real-time acquisition of photoplethysmographic (PPG) and galvanic skin response (GSR) signals. The device integrates both the PPG and GSR sensors onto a single probe that can be easily placed on the finger, thereby minimizing the device footprint and overall size. The system enables the e…

Spectral analysis of the beat-to-beat variability of arterial compliance

2022

Arterial compliance is an important parameter influencing ventricular-arterial coupling, depending on structural and functional mechanics of arteries. In this study, the spontaneous beat-to-beat variability of arterial compliance was investigated in time and frequency domains in thirty-nine young and healthy subjects monitored in the supine resting state and during head-up tilt. Spectral decomposition was applied to retrieve the spectral content of the time series associated to low (LF) and high frequency (HF) oscillatory components. Our results highlight: (i) a decrease of arterial compliance with tilt, in agreement with previous studies; (ii) an increase of the LF power content concurrent…