Search results for " Cancer"

Modulation of salivary inflammatory markers and proteomic analysis in HNC and OSCC patients undergoing radiotherapy

2021

Head and neck cancer (HNC) includes malignant tumours that most commonly arise from the oral mucosa or lining of the head and neck regions. They are characterized according to their primary site of origin as malignancies of the nasal cavity and paranasal sinuses, pharynx, larynx, salivary glands and oral cavity. The majority of these neoplasms are epithelial tumours, among them the 90% are squamous cell carcinomas (SCC). HNC including the Oral Squamous cell carcinoma (OSCC), is the sixth most common neoplasia worldwide with an incidence estimated at 650,000 cases and 330,000 deaths per year. Despite all of the diagnostic and therapeutic advances, the 5-year survival rate remains relatively …

Can cystic lesions of the jaws be considered as the cause of mandibular asymmetry?

2021

The aim of this study is to investigate the presence of condylar and ramal asymmetry in patients with a cyst larger than 10 mm in the maxilla or mandible. Condylar and ramal asymmetry index measurements of 47 patients (mean age: 28.85 ± 15.348) in the study group and 40 patients in the control group (mean age: 33.73 ± 13.095) were performed using panoramic radiographs. The study group consists of patients with cysts larger than 10 mm in diameter in the maxilla or mandible. The control group consisted of patients with no radiolucent lesions and no history of trauma. The possible statistical difference between the groups was evaluated by the Mann-Whitney U test. No statistically significant d…

Could a Behavioral Model Explain Adherence to Second-Level Colonoscopy for Colon Cancer Screening? Results of a Cross-Sectional Study of the Palermo …

2022

According to Italian Essential Levels of Assistance (ELA), a colonoscopy is strongly recommended after a positive fecal occult blood test (FOBT) due to its effectiveness in early colorectal cancer detection. Despite the evidence, the Palermo province population (Italy), after a positive FOBT, have a lower colonoscopy adherence compared to Italian standards. This cross-sectional study analyzed patients’ perceptions of colonoscopy procedures to understand the reasons for non-adherence. Patients with a positive FOBT who did not undergo a colonoscopy within the national organized screening program were administered a telephone interview based on the Health Belief Model (HBM) questionnaire. The …

Efficacy of the Cognitively-Based Compassion Training (CBCT®) Program for the improvement of Quality of Life and Fear of Cancer Recurrence in a sampl…

2018

Existe un vasto cuerpo de investigación que evalúa los efectos de las intervenciones psicosociales sobre la adaptación psicológica durante el tratamiento del cáncer (Antoni, 2013; Guo et al., 2013; Stanton, 2006; Stanton, Luecken, MacKinnon y Thompson, 2013). En entornos oncológicos, las intervenciones basadas en Mindfulness han demostrado su eficacia para promover el bienestar y los dominios de calidad de vida (Sinatra y Black, 2018; Zainal, Booth y Huppert, 2013), estrategias de afrontamiento constructivas frente al estrés psicosocial relacionado con la enfermedad, aliviando la ansiedad, el estrés, la fatiga, el estado de ánimo general, la alteración del sueño (Carlson et al., 2003; Carls…

HER-2 marķiera noteikšana krūts vēža pacientēm neoadjuvantas ķīmijterapijas laikā

2021

Ievads. Onkomarķieriem ir īpaša nozīme ļaundabīgo slimību diagnostikā un ārstēšanas efektivitātes prognozēšanā. HER-2 receptora ekspresija raksturīga vidēji 15-30% krūts vēža audzējiem un ir saistīta ar agresīvu audzēja gaitu. Audzēja HER-2 ekspresiju nosaka biopsijas materiālā. Savukārt, ekstracelulāro HER-2 domēnu iespējams noteikt asins serumā. Seruma HER-2 var būt noteikts arī veseliem pacientiem, taču, tā koncentrācija ir augstāka pacientiem ar krūts vēzi, īpaši ja audzējs ir HER-2 receptoru pozitīvs. Izteikts seruma HER-2 koncentrācijas samazinājums ķīmijterapijas laikā var būt saistīts ar labāku atbildi uz terapiju, ilgāku laiku līdz slimības progresijai un garāku kopējo dzīvildzi. D…

"Evaluating the prognostic role of serum extracellular domain (ECD) of HER-2/neu (s-HER2) in patients (PTS) with early (E) breast cancer (BC)”

2009

Effects of ectopic expression of NGAL on doxorubicin sensitivity.

2012

Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

2013

Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…

Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and…

2022

Currently, the most frequently employed therapies in the treatment of inflammatory bowel diseases (IBD), i.e., Crohn's Disease (CD), Ulcerative Colitis (UC) or unclassified IBD (IBD-U) are monoclonal anti-TNFs and anti-integrin therapies, such as vedolizumab (VDZ). Forty-seven per cent of these patients present extra-intestinal manifestations, the second most prevalent being aphthous stomatitis (AS). The present study aims to investigate which of the two therapies is associated with a lower prevalence of AS after treatment. An electronic search of the MEDLINE (via PubMed), Web of Science, SCOPUS, LILACS and OpenGrey databases was carried out. The criteria used were those described by the PR…

Prognostic value of HSP27 in head and neck squamous cell carcinoma: a retrospective analysis of 57 tumours.

2006

Background: The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma (OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC. Materials and Methods: The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM, staging and survival rate. Univariate and multivariate analyses were performed. Results: HSP27 was found to be reduced in 31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP…