Search results for " Candida"
showing 10 items of 104 documents
Selection and Gratitude: Anonymity and gratitude
2018
What kind of candidate is selected into a job when the principal has to appoint a committee to measure the candidate's ability and select a winner through a call specifying a wage for the job? In a model where the principal fixes the wage anticipating the committee's choice, under a rather natural assumption about the committee's objective we find that if the committee takes into account the candidate's gratitude a candidate with less than first best ability will be selected in equilibrium. First best selection is achieved if the committee is anonymous to the candidates. If the committee could also set the wage the first best candidate would be selected, but the principal would be worse off…
Transcriptome profiling of citrus fruit response to huanglongbing disease.
2010
Huanglongbing (HLB) or "citrus greening" is the most destructive citrus disease worldwide. In this work, we studied host responses of citrus to infection with Candidatus Liberibacter asiaticus (CaLas) using next-generation sequencing technologies. A deep mRNA profile was obtained from peel of healthy and HLB- affected fruit. It was followed by pathway and protein-protein network analysis and quantitative real time PCR analysis of highly regulated genes. We identified differentially regulated pathways and constructed networks that provide a deep insight into the metabolism of affected fruit. Data mining revealed that HLB enhanced transcription of genes involved in the light reactions of phot…
Genome-wide detection of signatures of selection in three Valdostana cattle populations
2020
International audience; The Valdostana is a local dual purpose cattle breed developed in Italy. Three populations are recognized within this breed, based on coat colour, production level, morphology and temperament: Valdostana Red Pied (VPR), Valdostana Black Pied (VPN) and Valdostana Chestnut (VCA). Here, we investigated putative genomic regions under selection among these three populations using the Bovine 50K SNP array by combining three different statistical methods based either on allele frequencies (F-ST) or extended haplotype homozygosity (iHS and Rsb). In total, 8, 5 and 8 chromosomes harbouring 13, 13 and 16 genomic regions potentially under selection were identified by at least tw…
Como superar el proceso de selección de consultoría estratégica
2016
El propósito de este trabajo es proporcionar al lector las herramientas necesarias para superar con éxito el proceso de selección de las principales consultoras estratégicas. Para ello, nos centramos principalmente en resolver dos cuestiones: ¿Cómo conseguir la entrevista? y ¿Cómo superar la entrevista? La respuesta a estos interrogantes requiere analizar todos los pasos del proceso de selección, desde el perfil del candidato idóneo hasta las preguntas que éste debe realizar al entrevistador cuando finalice la entrevista, poniendo especial énfasis en la denominada entrevista-caso. Como consecuencia, observaremos que la consecución de un puesto de trabajo en la industria depende principalmen…
Proteomic analysis highlights the role of detoxification pathways in increased tolerance to Huanglongbing disease.
2016
Background Huanglongbing (HLB) disease is still the greatest threat to citriculture worldwide. Although there is not any resistance source in the Citrus germplasm, a certain level of moderated tolerance is present. A large-scale analysis of proteomic responses of Citrus may help: 1) clarifying physiological and molecular effects of disease progression, 2) validating previous data at transcriptomic level, and 3) identifying biomarkers for development of early diagnostics, short-term therapeutics and long-term genetic resistance. Results In this work we have conducted a proteomic analysis of mature leaves of two Citrus genotypes with well-known differing tolerances to HLB: Navel orange (highl…
Nonverbal Influence During Televised Debates
2016
Experimental studies find a strong influence of nonverbal signals on the evaluation of political candidates when raters are asked to judge unknown candidates from short-duration exposures. Yet when viewers are exposed to candidates’ verbal and nonverbal communication in a more naturally occurring context, the presence of verbal communication can make the influence of nonverbal communication seem attenuated. To link these findings, the present study uses continuous response measurement to uncover the relative influence of verbal and nonverbal communication on political opinion formation during a debate clip lasting about 9 minutes. The analysis suggests that nonverbal communication influenc…
The frontier between cell and organelle: genome analysis of Candidatus Carsonella ruddii
2007
Background Bacterial symbioses are widespread among insects. The early establishment of such symbiotic associations has probably been one of the key factors for the evolutionary success of insects, since it may have allowed access to novel ecological niches and to new imbalanced food resources, such as plant sap or blood. Several genomes of bacterial endosymbionts of different insect species have been recently sequenced, and their biology has been extensively studied. Recently, the complete genome sequence of Candidatus Carsonella ruddii, considered the primary endosymbiont of the psyllid Pachpsylla venusta, has been published. This genome consists of a circular chromosome of 159,662 bp and…
Nomination for inscription on the World Heritage List Unesco. Arab-Norman Palermo and cathedral churches of Cefalù and Monreale
2012
Il dossier di candidatura per l'iscrizione nella WHL rappresentano l’insieme degli edifici costituenti l’itinerario arabo normanno rappresentano un eccezionale valore universale come esempio di convivenza e interazione tra diverse componenti culturali di provenienza storica e geografica eterogenea (sincretismo culturale). Tale fenomeno ha generato uno stile architettonico originale in cui sono mirabilmente fusi elementi bizantini, islamici e romanici, capace di volta in volta di prodursi in combinazioni uniche, di eccelso valore artistico e straordinariamente unitarie
Positron emission tomography in CNS drug discovery and drug monitoring.
2014
Molecular imaging methods such as positron emission tomography (PET) are increasingly involved in the development of new drugs. Using radioactive tracers as imaging probes, PET allows the determination of the pharmacokinetic and pharmacodynamic properties of a drug candidate, via recording target engagement, the pattern of distribution, and metabolism. Because of the noninvasive nature and quantitative end point obtainable by molecular imaging, it seems inherently suited for the examination of a pharmaceutical’s behavior in the brain. Molecular imaging, most especially PET, can therefore be a valuable tool in CNS drug research. In this Perspective, we present the basic principles of PET, th…