Search results for " Cellular"
showing 10 items of 384 documents
Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients Is Associated with Protracted Cold Ischemic Time of Seropositive Donor O…
2017
Human Cytomegalovirus (CMV) can lead to primary infection or reactivation in CMV-seronegative or -seropositive kidney transplant recipients, respectively. Complications comprise severe end-organ diseases and acute or chronic transplant rejection. Risk for CMV manifestation is stratified according to the CMV-IgG-serostatus, with donor+/recipient- (D+/R-) patients carrying the highest risk for CMV-replication. However, risk factors predisposing for primary infection in CMV-seronegative recipients are still not fully elucidated. Therefore, we monitored D+/R- high-risk patients undergoing kidney transplantation in combination with antiviral prophylaxis for the incidence of CMV-viremia for a med…
High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells
2020
Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and is one of the most common hematological malignancies. The potential effect of cannabinoids on the immune system and hematological malignancies has been poorly characterized. Cannabidiol (CBD) may be used to treat various diseases. CBD is known to exert immunomodulatory effects through the activation of cannabinoid receptor 2 (CB2), which is expressed in high levels in the hematopoietic system. Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T lymphocytes obtained via ex vivo sequential incubation of peripheral blood mononuclear cells (PBMCs) with interferon-&gam…
Clinical trials with combination of cytokine-induced killer cells and dendritic cells for cancer therapy
2019
Adoptive cellular immunotherapy (ACI) is a promising treatment for a number of cancers. Cytokine-induced killer cells (CIKs) are considered to be major cytotoxic immunologic effector cells. Usually cancer cells are able to suppress antitumor responses by secreting immunosuppressive factors. CIKs have significant antitumor activity and are capable of eradicating tumors with few side effects. They are a very encouraging cell population used against hematological and solid tumors, with an inexpensive expansion protocol which could yield to superior clinical outcome in clinical trials employing adoptive cellular therapy combination. In the last decade, clinical protocols have been modified by e…
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunosel…
1996
Antigenic peptides derived from differentiation antigens of the melanocyte lineage were recently identified in human melanomas as targets for MHC-restricted cytotoxic T lymphocytes (CTL). CTL directed against peptides derived from the Melan A/MART-1, tyrosinase and gp100/Pmel17 antigens can be detected in melanoma patients and in healthy controls. The presence of defined antigenic peptides and corresponding precursor CTL in patients with metastatic melanoma opens perspectives for the development of antigen-specific tumor vaccines. In this study, we examined the expression of Melan A/MART-1, tyrosinase and gp100lPmel17 in fresh melanoma tissues of HLA-A2+ patients and the spontaneous CTL rea…
A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice
2020
We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1lp.S78G mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (m.G14904A, mt-Cybp.D254N), affecting the CIII subunit cytochrome b (MT-CYB), in the background with short survival. We utilize maternal inheritance of mtDNA to confirm this as the causative variant and show that it further decreases the low CIII activity in Bcs1lp.S78G tissues to below survival threshold by 35 days of age. Molecular dynamics simulations predict D254N to restrict the flexibility of MT-CYB ef loop, potentially affecting RISP dyna…
Superiority Of One-Way And Realtime Quantum Machines
2012
In automata theory, quantum computation has been widely examined for finite state machines, known as quantum finite automata (QFAs), and less attention has been given to QFAs augmented with counters or stacks. In this paper, we focus on such generalizations of QFAs where the input head operates in one-way or realtime mode, and present some new results regarding their superiority over their classical counterparts. Our first result is about the nondeterministic acceptance mode: Each quantum model architecturally intermediate between realtime finite state automaton and one-way pushdown automaton (one-way finite automaton, realtime and one-way finite automata with one-counter, and realtime push…
Language Recognition Power and Succinctness of Affine Automata
2016
In this work we study a non-linear generalization based on affine transformations of probabilistic and quantum automata proposed recently by Diaz-Caro and Yakaryilmaz [6] referred as affine automata. First, we present efficient simulations of probabilistic and quantum automata by means of affine automata which allows us to characterize the class of exclusive stochastic languages. Then, we initiate a study on the succintness of affine automata. In particular, we show that an infinite family of unary regular languages can be recognized by 2-state affine automata, whereas the number of states of any quantum and probabilistic automata cannot be bounded. Finally, we present the characterization …
Quantum Pushdown Automata
2000
Quantum finite automata, as well as quantum pushdown automata were first introduced by C. Moore, J. P. Crutchfield [13]. In this paper we introduce the notion of quantum pushdown automata (QPA) in a non-equivalent way, including unitarity criteria, by using the definition of quantum finite automata of [11]. It is established that the unitarity criteria of QPA are not equivalent to the corresponding unitarity criteria of quantum Turing machines [4]. We show that QPA can recognize every regular language. Finally we present some simple languages recognized by QPA, two of them are not recognizable by deterministic pushdown automata and one seems to be not recognizable by probabilistic pushdown …
Postselection Finite Quantum Automata
2010
Postselection for quantum computing devices was introduced by S. Aaronson[2] as an excitingly efficient tool to solve long standing problems of computational complexity related to classical computing devices only. This was a surprising usage of notions of quantum computation. We introduce Aaronson's type postselection in quantum finite automata. There are several nonequivalent definitions of quantumfinite automata. Nearly all of them recognize only regular languages but not all regular languages. We prove that PALINDROMES can be recognized by MM-quantum finite automata with postselection. At first we prove by a direct construction that the complement of this language can be recognized this …
Quantum Finite Multitape Automata
1999
Quantum finite automata were introduced by C. Moore, J. P. Crutchfield [4], and by A. Kondacs and J. Watrous [3]. This notion is not a generalization of the deterministic finite automata. Moreover, in [3] it was proved that not all regular languages can be recognized by quantum finite automata. A. Ambainis and R. Freivalds [1] proved that for some languages quantum finite automata may be exponentially more concise rather than both deterministic and probabilistic finite automata. In this paper we introduce the notion of quantum finite multitape automata and prove that there is a language recognized by a quantum finite automaton but not by deterministic or probabilistic finite automata. This …