Search results for " Comorbidity"

showing 10 items of 87 documents

Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry

2020

Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patient…

Malemedicine.medical_specialtyChronic ObstructiveCirrhosisSocio-culturaleComorbidity030204 cardiovascular system & hematologycomorbiditieselderlyPulmonary Disease03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicine80 and overCOPDHumans030212 general & internal medicineLS4_4RegistriesHospital MortalityCOPD comorbidities elderly internal medicine in-hospital mortality.Depression (differential diagnoses)Cause of deathAgedRetrospective Studies1-year mortality; 3-month mortality; COPD; comorbidities; elderly; internal medicine; in-hospital mortalityAged 80 and overCOPDbusiness.industry1-year mortality; 3-month mortality; COPD comorbidities elderly internal medicine in-hospital mortalitymedicine.diseaseIm - Original1-year mortality; 3-month mortality; COPD comorbidities elderly internal medicine in-hospital mortality; Aged; Aged 80 and over; Comorbidity; Female; Humans; Internal Medicine; Male; Pulmonary Disease Chronic Obstructive; Registries; Retrospective Studies; Hospital Mortalityinternal medicineClinical diagnosisCohortEmergency Medicine1-year mortality3-month mortalityCOPD comorbidities elderly internal medicine in-hospital mortality1-year mortality 3-month mortality COPD comorbidities elderly internal medicine in-hospital mortality.Observational studyFemalebusiness1 year mortalityin-hospital mortality
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Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

2019

Abstract Background Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migraine. Defining the exact nature of the association between migraine and psychiatric disorders and bringing out the pathophysiological mechanisms underlying the comorbidity with psychiatric conditions are relevant issues in the clinical practice. Methods A systematic review of the most relevant studies about migraine and psychiatric comorbidity was performed using “PubMed”, “Scopus”, and “ScienceDirect” electronic databases from 1 January 1998 to 15 July 2018. Overall, …

Malemedicine.medical_specialtyDatabases Factualbiological pathways; comorbidity; migraine; psychiatric disordersMigraine DisordersBiological pathwayslcsh:MedicineNeurological disorderReview ArticleComorbidityBiological pathways; Comorbidity; Migraine; Psychiatric disorders; Comorbidity; Databases Factual; Depressive Disorder Major; Disabled Persons; Female; Humans; Male; Mental Disorders; Migraine Disorders; Prevalence; Treatment Outcome03 medical and health sciencesDatabases0302 clinical medicineChronic MigrainemedicinePrevalenceHumansDisabled Persons030212 general & internal medicinePsychiatryDepression (differential diagnoses)FactualMigraineDepressive Disorder MajorDepressive Disorderbusiness.industryPanic disorderMental Disorderslcsh:RMajorGeneral Medicinemedicine.diseaseComorbidityMigraine with auraAnesthesiology and Pain MedicineTreatment OutcomeMigraineFemaleNeurology (clinical)medicine.symptombusinessPsychiatric disordersPsychosocial030217 neurology & neurosurgery
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Disability, and not diabetes, is a strong predictor of mortality in oldest old patients hospitalized with pneumonia

2018

Abstract Background Pneumonia causes more deaths than any other infectious disease, especially in older patients with multiple chronic diseases. Recent studies identified a low functional status as prognostic factor for mortality in elderly patients with pneumonia while contrasting data are available about the role of diabetes. The aim of this study was to evaluate the in-hospital, 3-month and 1-year mortality in elderly subjects affected by pneumonia enrolled in the RePoSi register. Methods We retrospectively analyzed the data collected on hospitalized elderly patients in the frame of the REPOSI project. We analyzed the socio-demographic, laboratory and clinical characteristics of subjects…

Malemedicine.medical_specialtyMultivariate analysisBarthel indexSocio-culturaleComorbidity030204 cardiovascular system & hematologyDiabeteSeverity of Illness IndexComorbidity; Diabetes; Disability; Elderly; Pneumonia; Aged; Aged 80 and over; Comorbidity; Diabetes Mellitus; Disabled Persons; Female; Geriatric Assessment; Hospitalization; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Pneumonia; Retrospective Studies; Risk Factors; Severity of Illness Index03 medical and health sciences0302 clinical medicineElderlyRisk FactorsDiabetes mellitusInternal medicineSeverity of illnessmedicine80 and overDiabetes MellitusInternal MedicineHumansDisabled Persons030212 general & internal medicineGeriatric AssessmentAgedRetrospective StudiesAged 80 and overDisabilitybusiness.industrySettore MED/09 - MEDICINA INTERNADiabetesRetrospective cohort studyOdds ratioPneumoniamedicine.diseaseOldest oldComorbidityPneumonia; Elderly; Disability; Diabetes; ComorbidityHospitalizationLogistic ModelsItalyMultivariate AnalysisFemaleComorbidity Diabetes Disability Elderly Pneumoniabusiness
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Early endovascular aneurysm repair after percutaneous coronary interventions

2015

Objective The objective of this study was to report long-term results of early endovascular aortic aneurysm repair after percutaneous coronary intervention (PCI). Methods This was a retrospective analysis of all patients presenting with abdominal aortic aneurysm and coronary artery disease treated during the same hospitalization by endovascular aortic aneurysm repair performed soon after PCI. Primary outcomes were perioperative mortality, perioperative complications, survival after treatment, and freedom from reintervention. Results A total of 20 patients were included, and all completed both procedures. No deaths or abdominal aortic aneurysm ruptures occurred between the PCI and the aortic…

Malemedicine.medical_treatmentCoronary DiseaseComorbidityEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareCoronary artery diseaseAortic aneurysmPostoperative ComplicationsRisk FactorsRetrospective StudieCause of DeathMyocardial infarctionHospital MortalityAged; Aged 80 and over; Aortic Aneurysm Abdominal; Cause of Death; Combined Modality Therapy; Comorbidity; Coronary Disease; Follow-Up Studies; Hospital Mortality; Humans; Italy; Male; Middle Aged; Postoperative Complications; Reoperation; Retrospective Studies; Risk Factors; Survival Rate; Early Medical Intervention; Percutaneous Coronary Intervention; Cardiology and Cardiovascular Medicine; Surgery; Medicine (all)Aged 80 and overMedicine (all)Middle AgedCombined Modality TherapyAbdominal aortic aneurysm2746 SurgerySurvival RateItalycardiovascular systemCardiologyCardiology and Cardiovascular MedicineHumanReoperationmedicine.medical_specialty10216 Institute of Anesthesiology610 Medicine & health2705 Cardiology and Cardiovascular MedicineFollow-Up StudiePercutaneous Coronary InterventionInternal medicineEarly Medical InterventionmedicineHumanscardiovascular diseasesRetrospective StudiesAgedbusiness.industryRisk FactorPercutaneous coronary interventionPerioperativemedicine.disease10020 Clinic for Cardiac SurgerySurgeryConventional PCISurgeryPostoperative ComplicationbusinessFollow-Up StudiesAortic Aneurysm Abdominal
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Opioid switching in patients with advanced cancer followed at home. A retrospective analysis.

2013

Abstract CONTEXT: Opioid switching has been found to improve opioid responsiveness in different conditions. However, data on opioid switching performed at home are almost nonexistent, despite the fact that most patients are followed at home. OBJECTIVES: The aim of this retrospective survey was to determine frequency, indications, usefulness, and safety of opioid switching when treating advanced cancer-related pain in patients followed at home. METHODS: A retrospective review of data from patients with advanced cancer followed at home by three home care teams for a period of two years was performed. Patients who had their opioids switched were selected. Reasons for switching opioid doses and…

Maleretrospective studyComorbiditySettore MED/42 - Igiene Generale E Applicataadvanced cancer patientNeoplasmsRetrospective analysisPrevalenceOpioid switching; advanced cancer patients; retrospective studyCancer painProspective cohort studyNursing (all)2901 Nursing (miscellaneous)General NursingAnalgesicsDrug SubstitutionHome Care ServicesAnalgesics OpioidCausalitySurvival RateTreatment OutcomeItalyFemaleDrugmedicine.drugmedicine.medical_specialtyAnalgesicPainContext (language use)OpioidDose-Response RelationshipmedicineHumansIn patientIntensive care medicineAgedRetrospective StudiesDose-Response Relationship Drugbusiness.industryAdvanced cancerSurvival AnalysisCancer pain; home care; opioid switching; Aged; Analgesics Opioid; Causality; Comorbidity; Dose-Response Relationship Drug; Drug Substitution; Female; Home Care Services; Humans; Italy; Male; Neoplasms; Pain; Prevalence; Quality of Life; Retrospective Studies; Survival Analysis; Survival Rate; Treatment Outcome; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)Anesthesiology and Pain MedicineOpioidEmergency medicineMorphineOpioid switchingQuality of LifeNeurology (clinical)home carebusinessJournal of pain and symptom management
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Current and future challenges in HCV: insights from an Italian experts panel

2017

Background: The recent availability of direct acting antiviral drugs (DAAs) has drastically changed hepatitis C virus (HCV) treatment scenarios, due to the exceedingly high rates of sustained virological response (SVR) and excellent tolerability allowing for treatment at all disease stages. Methods: A panel of Italian experts was convened twice, in November 2016 and January 2017, to provide further support on some open issues and provide guidance for personalized HCV care, also in light of forthcoming regimens. Results and conclusions: Treatment recommendations issued by international and national liver societies to guide clinicians in the management of HCV infection are constantly updated …

Microbiology (medical)medicine.medical_specialtySettore MED/17 - Malattie InfettiveDisease stagesComorbidityAntiviral AgentsComorbiditiesVirological response03 medical and health sciences0302 clinical medicineComorbidities; DAAs; HCV; Treatment; Microbiology (medical); Infectious DiseasesmedicineHumans030212 general & internal medicineIntensive care medicineDAAHigh rateComorbidities; DAAs; HCV; Treatmentbusiness.industryDAAsGeneral MedicineHepatitis Cmedicine.diseaseHepatitis CVirologyTreatmentInfectious DiseasesItalyTolerabilityComorbidities; DAAs; HCV; Treatment; Comorbidity; Hepatitis C; Humans; Italy; Antiviral AgentsHealthcare settingsHCV030211 gastroenterology & hepatologyComorbiditiebusinessDirect acting
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The Assessment of Risk Factors for Long-term Survival Outcome in ypN0 Patients With Rectal Cancer After Neoadjuvant Therapy and Radical Anterior Rese…

2021

Abstract Background The main negative prognostic factors in patients with rectal cancer after radical treatment include regional lymph node involvement, lymphovascular invasion, and perineural invasion. However, some patients still develop cancer recurrence despite the absence of the above risk factors. The aim of the study was to assess clinicopathological factors influencing long-term oncologic outcomes in ypN0M0 rectal cancer patients after neoadjuvant therapy and radical anterior resection. Methods A retrospective survival analysis was performed on a group of 195 patients. We assessed clinicopathological factors which included tumor regression grade, number of lymph nodes in the specime…

OncologyAnterior rectal resectionmedicine.medical_specialtyRD1-811Lymphovascular invasionColorectal cancermedicine.medical_treatmentPerineural invasion030230 surgeryDisease-Free Survival03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineLymph node yieldHumansLymph nodeNeoadjuvant therapySurvival analysisRC254-282Neoplasm StagingRetrospective StudiesTumor Regression GradeUnivariate analysisbusiness.industryLate anastomotic leakRectal NeoplasmsResearchNeoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseasePrognosisNeoadjuvant Therapymedicine.anatomical_structureOncologyStage migration030220 oncology & carcinogenesisSurgeryNeoplasm Recurrence LocalbusinessCharlson comorbidity index
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Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents.

2021

Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical stud…

Oncologyendocrine system diseasesColorectal cancerComorbidityReview0302 clinical medicineinsulin resistanceEpidemiologyBiology (General)small dense LDLSpectroscopyglucagon-like peptide-1 receptor agonists0303 health sciencesIncidenceGeneral MedicineSmall dense LDL3. Good healthComputer Science ApplicationsLipoproteins LDLChemistry030220 oncology & carcinogenesismedicine.symptomColorectal Neoplasmsmedicine.medical_specialtyQH301-705.5InflammationCatalysisGlucagon-like peptide-1 receptor agonistsGlucagon-Like Peptide-1 ReceptorInorganic Chemistry03 medical and health sciencesInsulin resistanceInternal medicineDiabetes mellitusmedicineHumansHypoglycemic AgentsIn patientPhysical and Theoretical ChemistryQD1-999Molecular BiologyAntidiabetic agents030304 developmental biologyInflammationbusiness.industryOrganic ChemistryType 2 Diabetes Mellitusnutritional and metabolic diseasesInsulin resistanceGlucagon-like peptide-1 receptor agonists Hyperglycemia Inflammation Insulin resistance Comorbidity Diabetes Mellitus Type 2 Glucagon-Like Peptide-1 Receptor Humans Hyperglycemia Hypoglycemic Agents Incidence Lipoproteins LDL Oxidative Stress Colorectal Neoplasms Small dense LDLmedicine.diseasedigestive system diseasesOxidative StressDiabetes Mellitus Type 2Oxidative stressinflammationHyperglycemiabusinessInternational journal of molecular sciences
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Rethinking Dual Disorders/Pathology

2013

Objective:Comorbidity of addictive disorders and other psychiatric disorders is very common. The optimal treatment of patients with addiction disorders requires awareness of their comorbid mental disorders and vice versa. The operational and contextual definitions of the different terms used vary si

Pathologymedicine.medical_specialtybusiness.industryOptimal treatmentAddictionmedia_common.quotation_subjectMedicine (miscellaneous)DUAL (cognitive architecture)medicine.diseaseComorbidityPsychiatry and Mental healthPsychiatric comorbiditymental disordersMedicinebusinessmedia_commonAddictive Disorders & Their Treatment
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LATE-BREAKING ABSTRACT: Phenotypes of COPD in central and Eastern Europe - The POPE study

2015

Introduction: Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries. However, data regarding symptom load and clinical phenotypes of patients with COPD in CEE remain largely unknown. Methods: Participation in the POPE Study (a multicentre, observational cross-sectional survey) was offered to consecutive outpatients with stable COPD in 11 CEE countries if they fulfilled the following criteria: age ≥ 40 years, smoking history ≥ 10 pack-years, post-bronchodilator (BD) FEV 1 /FVC Results: 3504 patients (66 ± 8.7 yrs, 69% male, post-BD FEV 1 53.0 ± 17.5% predicted, Charlson comorbidity index 2.0 ± 1.4, and 1.2 ± 1.6 exacerb…

Pediatricsmedicine.medical_specialtyCOPDeducation.field_of_studyChronic bronchitisbusiness.industryPopulationOverlap syndromemedicine.diseaserespiratory tract diseases3. Good healthEastern europeanFEV1/FVC ratioCharlson comorbidity indexmedicineObservational studybusinesseducation1.1 Clinical Problems
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